海南医学院学报2018，Vol.24Issue(8)：861-864,4.DOI:10.13210/j.cnki.jhmu.20180327.002
真武汤联合紫杉醇新辅助化疗对宫颈癌病灶恶性程度的影响
Effect of Zhenwu decoction combined with paclitaxel neoadjuvant chemotherapy on the malignant degree of cervical cancer
摘要
Abstract
Objective:To study the effect of Zhenwu decoction combined with paclitaxel neoadjuvant chemotherapy on the malignant degree of cervical cancer.Methods:Patients with cervical cancer who accepted neoadjuvant chemotherapy in Nanchong Central Hospital and Suining Central Hospital between March 2015 and June 2017 were selected and randomly divided into two groups,the observation group received neoadjuvant chemotherapy combined with Zhenwu decoction therapy,and the control group received neoadjuvant chemotherapy.Before chemotherapy and after 2 courses of chemotherapy,the serum was collected to detect the contents of tumor markers;after chemotherapy,the surgically removed cervical cancer lesion was collected to detect the mRNA expression of proliferation genes,tumor suppressor genes and invasion genes.Results:After 2 course of chemotherapy,CA12-5,bFGF and SCC-Ag levels in serum of both groups were lower than those before treatment,and CA12-5,bFGF and SCC-Ag levels in serum as well as Ki-67,TK-1,SOX-2,CyclinD1,S100A6,N-cadherin,Gal-3,CatL and CatD mRNA expression in cervical cancer lesion of observation group were lower than those of control group whereas p53,p16,FHIT,NF2-1 and LATS1 mRNA expression in cervical cancer lesions were higher than those of control group (P ＜ 0.05).Conclusion:Zhenwu decoction combined with paclitaxel neoadjuvant chemotherapy can be more effective than neoadjuvant chemotherapy alone to kill cervical cancer cells and reduce the malignancy of cervical cancer.关键词
宫颈癌/新辅助化疗/真武汤/增殖/抑癌基因/侵袭Key words
Cervical cancer/Neoadjuvant chemotherapy/Zhenwu decoction/Proliferation/Tumor suppressor gene/Invasion分类
医药卫生引用本文复制引用
强红梅,唐军伟,赵荣,李小娣..真武汤联合紫杉醇新辅助化疗对宫颈癌病灶恶性程度的影响[J].海南医学院学报,2018,24(8):861-864,4.基金项目
This study was supported by Special Research Project on TCM Science and Technology in Sichuan Province (Grant No.2016Q088).四川省中医药科学技术研究专项(2016Q088) （Grant No.2016Q088）
