海南医学院学报2018，Vol.24Issue(8)：865-868,4.DOI:10.13210/j.cnki.jhmu.20180417.001
氯胺酮联合利多卡因超前镇痛对宫颈癌患者术后疼痛、炎症、应激反应的影响
Effects of ketamine combined with lidocaine for preemptive analgesia on postoperative pain, inflammatory response and stress response in patients with cervical cancer
摘要
Abstract
Objective:To investigate the effects of ketamine combined with lidocaine for preemptive analgesia on postoperative pain,inflammatory response and stress response in patients with cervical cancer.Methods:68 patients with cervical cancer who received radical operation in the hospital between July 2016 and May 2017 were divided into routine analgesia group (n =37) and ketamine group (n =31) according to the postoperative analgesic solution.Routine analgesia group received lidocaine for preemptive analgesia and ketamine group received ketamine combined with lidocaine for preemptive analgesia.The differences in serum levels of pain mediators,inflammatory factors and stress hormones were compared between the two groups before surgery (T0),immediately after postoperative recovery (T1) and 24h after surgery (T2).Results:At T0,there was no statistically significant difference in serum levels of pain mediators,inflammatory factors and stress hormones between the two groups.At T1 and T2,serum pain mediators SP and NPY levels of ketamine group were lower than those of routine analgesia group;inflammatory factors IL-1β,IL-6 and IL-8 levels were lower than those of routine analgesia group;stress hormones Ang Ⅰ,Ang Ⅱ and NE levels were lower than those of routine analgesia group.Conclusion:Ketamine combined with lidocaine for preemptive analgesia can effectively suppress the early postoperative pain mediator secretion and relieve the systemic inflammatory response and stress response in patients with cervical cancer.关键词
宫颈癌/氯胺酮/疼痛/炎症反应/应激反应Key words
Cervical cancer/Ketamine/Pain/Inflammatory response/Stress response分类
医药卫生引用本文复制引用
陈新生,饶云霞..氯胺酮联合利多卡因超前镇痛对宫颈癌患者术后疼痛、炎症、应激反应的影响[J].海南医学院学报,2018,24(8):865-868,4.基金项目
It is supported by General Project of Health and Family Planning Commission in Hebei Province (WJ2012MB061).湖北省卫计委一般项目编号:WJ2012MB061 （WJ2012MB061）
