海南医学院学报2018，Vol.24Issue(8)：869-872,4.DOI:10.13210/j.cnki.jhmu.20180328.007
急性脑梗死合并阻塞性睡眠呼吸暂停综合征患者糖脂代谢特征、动脉粥样硬化特征评估
The characteristics of glycolipid metabolism as well as atherosclerosis in patients with obstructive sleep apnea-hypopnea syndrome combined with cerebral infarction
摘要
Abstract
Objective:To evaluate the characteristics of glycolipid metabolism as well as atherosclerosis in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) combined with cerebral infarction.Methods:Patients who were treated in the hospital due to acute cerebral infarction between March 2015 and February 2018 were selected,and according to the combination of OSAHS,the 300 patients with cerebral infarction were divided into the cerebral infarction group A who were combined with OSAHS and the cerebral infarction group B who were not combined with OSAHS;the 100 cases of healthy volunteers who underwent physical examination in our hospital during the same period were selected as the control group.The contents of glycolipid metabolism indexes,cytokines and plaque hydrolysis molecules in serum were determined.Results:Serum FIns,TC,LDL-C,VE-cadherin,YKL-40,FKN,M-CSF,MCP-1,MMP9,Caspase-3,ICTP and VCAM-1 levels of cerebral infarction group A and cerebral infarction group B were significantly higher than those of control group whereas HDL-C levels were significantly lower than those of control group (P＜0.05);serum F-Ins,TC,LDL-C,VE-cadherin,YKL-40,FKN,MCSF,MCP-1,MMP9,Caspase-3,ICTP and VCAM-1 levels of cerebral infarction group A were significantly higher than those of cerebral infarction group B whereas HDL-C level was significantly lower than that of cerebral infarction group B (P＜0.05).Conclusion:There are more significant glycolipid metabolism disorders and worse plaque stability in patients with OSAHS combined with cerebral cerebral infarction.关键词
脑梗死/阻塞性睡眠呼吸暂停综合征/糖脂代谢/动脉粥样硬化Key words
Cerebral infarction/Obstructive sleep apnea-hypopnea syndrome/Glycolipid metabolism/Atherosclerosis分类
医药卫生引用本文复制引用
蔡艳丽,郝建强,王海滨..急性脑梗死合并阻塞性睡眠呼吸暂停综合征患者糖脂代谢特征、动脉粥样硬化特征评估[J].海南医学院学报,2018,24(8):869-872,4.基金项目
This study was supported by Sichuan Provincial Medical Research Youth Innovation Project (Grant No.Q16004)四川省医学科研青年创新课题(Q16004) （Grant No.Q16004）
