海南医学院学报2018，Vol.24Issue(9)：918-922,5.DOI:10.13210/j.cnki.jhmu.20180411.002
右美托咪定用于颅脑损伤患者术后镇静对神经功能、炎症及氧化应激反应的影响
Effects of postoperative dexmedetomidine sedation on nerve function ,inflammation and oxidative stress in patients with craniocerebral injury
摘要
Abstract
Objective:To study the effects of postoperative dexmedetomidine sedation on nerve function ,inflammation and oxidative stress in patients with craniocerebral injury .Methods:Patients who were admitted to ICU and needed sedation and analgesia after craniocerebral injury craniotomy in Huiya Hospital between June 2016 and October 2017 were selected as the research subjects and divided into the Dex group who received postoperative dexmedetomidine sedation and the control group who received postoperative midazolam sedation according to the history data .The levels of nerve markers and inflammation molecules in serum as well as the expression of oxidative stress molecules in peripheral blood were measured before surgery as well as 24 h and 48 h after surgery .Results:Compared with those before surgery ,UCH-L1 ,NSE ,GFAP ,sFkn ,CXCL12 , IL-1βand sICAM1 levels in serum as well as Nrf2 ,NQO1 ,HO1 ,NOX2 and NOX4 expression in peripheral blood of both groups decreased significantly whereas BDNF and NGF levels increased significantly 24 h and 48 h after surgery ,and UCH-L1 , NSE ,GFAP ,sFkn ,CXCL12 ,IL-1βand sICAM1 levels in serum as well as Nrf2 ,NQO1 ,HO1 ,NOX2 and NOX4 expression in peripheral blood of Dex group 24 h and 48 h after surgery were significantly lower than those of control group whereas BDNF and NGF levels were significantly higher than those of control group .Conclusion:Dexmedetomidine for postoperative sedation can be more effective than midazolam to improve the nerve function ,reduce the inflammation and oxidative stress in patients with craniocerebral injury .关键词
颅脑损伤/右美托咪定/炎症反应/氧化应激反应Key words
Craniocerebral injury/Dexmedetomidine/Inflammation/Oxidative stress分类
医药卫生引用本文复制引用
林宗钦,李达宇,王海燕,关开泮..右美托咪定用于颅脑损伤患者术后镇静对神经功能、炎症及氧化应激反应的影响[J].海南医学院学报,2018,24(9):918-922,5.基金项目
广东省惠州市科技计划项目(20160810) （20160810）
This study was supported by Science and Technology Plan Project of Huizhou City in Guangdong Province (grant No.20160810). （grant No.20160810）
