解放军医药杂志2018，Vol.30Issue(5)：15-18,4.DOI:10.3969/j.issn.2095-140X.2018.05.004
血清肿瘤标志物胃泌素释放肽前体和神经特异性烯醇化酶在小细胞肺癌辅助诊断及疗效评价中的意义
Significances of Pro-gastrin Releasing Peptide and NSE in Auxiliary Diagnosis and Evaluation of Curative Effect of Small Cell Lung Cancer
摘要
Abstract
Objective To investigate significances of serum pro-gastrin releasing peptide (ProGRP) and neuron specific enolase (NSE) in auxiliary diagnosis and evaluation of curative effect of small cell lung cancer (SCLC). Meth-ods A total of 127 SCLC patients primitively diagnosed by pathologic results during January 2015 and March 2017 were selected as group A, and other 127 healthy people taking physical examination at the same period were selected as group B, and other 127 patients with non-small cell lung cancer (NSCLC) by initial pathologic diagnosis at the same period were selected as group C. In three groups, serum ProGRP and NSE levels were observed, and values and correlations with prognosis of ProGRP and NSE levels in diagnosis of SCLC were analyzed. Results ProGRP and NSE levels in group C were significantly higher than those in group B (P < 0. 05), and ProGRP and NSE levels in group A were significantly higher than those in group B and C (P < 0. 05). ProGRP and NSE levels of SCLC patients with extensive stage were sig-nificantly increased compared with those of SCLC patients with limitations period (P < 0. 05). Specificity of both positive ProGR and NSE (positive values≥the optimal cut-off value) in diagnosis of SCLC were significantly better than those by only positive ProGRP or NSE (P < 0. 05), while sensitivity of only positive ProGRP or NSE in diagnosis of SCLC was sig-nificantly better than that by both positive ProGR and NSE (P < 0. 05). ProGRP and NSE levels in invalid patients were significantly higher than those in effective patients (P < 0. 05). Conclusion Detection of serum ProGRP and NSE levels are helpful for diagnosis of SCLC, and curative effect of chemotherapy on SCLC has predictive value.关键词
小细胞肺癌/胃泌素释放肽/神经特异性烯醇化酶Key words
Small cell lung carcinoma/Gastrin releasing peptide/Neuron specific enolase分类
医药卫生引用本文复制引用
彭雄文,沈乐园,宋仕聪..血清肿瘤标志物胃泌素释放肽前体和神经特异性烯醇化酶在小细胞肺癌辅助诊断及疗效评价中的意义[J].解放军医药杂志,2018,30(5):15-18,4.基金项目
广东省自然科学基金(2016A030313755) （2016A030313755）
