解放军医药杂志2018，Vol.30Issue(5)：26-29,4.DOI:10.3969/j.issn.2095-140X.2018.05.007
适形放疗联合化疗治疗晚期膀胱癌效果观察
Effect of Conformal Radiotherapy Combined with Chemotherapy in Treatment of Patients with Advanced Blad-der Cancer
摘要
Abstract
Objective To observe effect of conformal radiotherapy combined with chemotherapy in treatment of patients with advanced bladder cancer. Methods A total of 76 patients with advanced bladder cancer admitted during February 2013 and May 2015 were divided into observation group (n = 38) and control group (n = 38) according to dif-ferent treatment methods. Control group was treated with chemotherapy, while observation group was treated with radio-therapy and chemotherapy. Therapeutic effect, Karnofsky (KPS) score, recurrence rate, survival rate, levels of related factors in urine and adverse reaction were analyzed in two groups. Results The total effective rate in observation group was significantly higher than that in control group (P < 0. 05). In 1 month after treatment, KPS scores were significantly higher than those before treatment in two groups (P < 0. 05). Within 6 months after treatment, recurrence rate in obser-vation group was significantly lower than that in control group (P < 0. 05). Within 1 year after treatment, recurrence rate in observation group was slightly lower than that in control group, but the difference was not statistically significant (P >0. 05). Survival rates in 1 year and 2 years in observation group were slightly higher than those in control group, but the difference was not statistically significant between groups (P > 0. 05). After treatment, levels of bladder tumor antigen, nuclear matrix protein , urine bladder cancer antigen were significantly lower than before treatment in two groups (P <0. 05), and the levels in observation group were significantly lower than those in control group (P < 0. 05). Incidence rates of III-IV adverse reactions were similar in two groups, but the differences showed no statistical significances between groups (P > 0. 05). Conclusion Chemotherapy combined with radiotherapy in treatment of patients with advanced blad-der cancer may improve short-term efficacy and quality of life in the near future, but it has no significant effects on long-term recurrence rate and survival rate, and radiotherapy will not obviously aggravate adverse reactions.关键词
膀胱肿瘤/放射疗法/药物疗法,联合/治疗结果Key words
Bladder neoplasms/Radiotherapy/Drug therapy/combination/Treatment outcome分类
医药卫生引用本文复制引用
熊军辉,傅斌,赵红,曾晓春,胡韶华,饶品浪,沈思瑶..适形放疗联合化疗治疗晚期膀胱癌效果观察[J].解放军医药杂志,2018,30(5):26-29,4.基金项目
江西卫计委普通科研项目(20151037) （20151037）
