检验医学与临床2018，Vol.15Issue(11)：1537-1541,5.DOI:10.3969/j.issn.1672-9455.2018.11.001
某院2013-2016年儿童呼吸道感染病原菌分布及耐药性分析
Analysis of the pathogenic bacteria distribution and drug resistance of children′s respiratory tract infection during 2013 to 2016
摘要
Abstract
Objective To investigate the distribution and the change of drug sensitivity of pathogenic bacte-ria in children′s respiratory tract infection during 2013 to 2016 ,and to provide reference for clinical treatment . Methods Specimens of children′s respiratory tract from the hospital during 2013 to 2016 were collected .Cul-tivation and identification were implemented according to standard operating procedure ,the antimicrobial sus-ceptibility was tested with K-B method (except Staphylococcus aureus with instrument method ) ,Results were interpreted with the CLSI 2016 Standard .All the data were analyzed with WHONET 5 .6 software . Results When the repeated strains from the same patient were screened out ,2136 strains of pathogenic bac-teria were isolated from 10220 specimens ,the positive rate was 20 .90％ ,of which 1247 were gram-negative bacilli (58 .38％ ) ,871 strains were gram-positive coccus (40 .78％ ) and 18 were fungi (0 .84％ ) .The most common pathogenic bacteria were Streptococcus pneumoniae (598 strains ,28 .00％ ) ,Haemophilus influenzae (244 strains ,11 .42％ ) ,Staphylococcus aureus (229 strains ,10 .72％ ) ,Pseudomonas aeruginosa (193 strains , 9 .04％ ) ,and Candida albicans (11 strains ,0 .51％ ) .In neonatal period ,the detection rate of Escherichia coli and Klebsiella pneumoniae was the highest .With the increase of age ,the detection rate of Streptococcus pneu-moniae and Haemophilus influenzae increased year by year .During 2013 to 2016 ,the detection rate of Hae-mophilus influenzae increased year by year ,and the detection rate of Escherichia coli decreased year by year . Streptococcus pneumoniae and Staphylococcus aureus were most sensitive to vancomycin and linezolid ,and the positive rate of methicillin resistant Staphylococcus aureus in Staphylococcus aureus was 22 .71％ .The positive rate of Haemophilus influenzae beta lactamase was 57 .79％ .The resistance rates of Pseudomonas aeruginosa to imipenem and meropenem were 12 .40％ and 11 .60％ respectively .Escherichia coli and Klebsiella pneumon-iae were more sensitive to carbapenems ,and the positive rates of extended spectrum beta lactamases were 54 .69％ and 42 .86％ respectively .Conclusion T he distribution of pathogenic bacteria and drug resistant changes of child respiratory infection had respective characteristics in the hospital .The detection of pathogenic bacteria and drug sensitivity test should be paid attention to ,and antibiotics should be used rationally to reduce the production of drug resistant strains .关键词
病原菌/耐药性/呼吸道感染/儿童Key words
pathogenic bacteria/drug resistance/respiratory infection/children分类
医药卫生引用本文复制引用
王丽萍,邵春红,范会,金炎..某院2013-2016年儿童呼吸道感染病原菌分布及耐药性分析[J].检验医学与临床,2018,15(11):1537-1541,5.基金项目
国家自然科学基金资助项目(81401696) （81401696）
山东省科技发展计划资助项目(2016GSF201078). （2016GSF201078）
