摘要
Abstract
Objective To investigate the association between serum free Triiodothyronine (FT3) and prog-nosis in patients with severe chronic heart failure (CHF) .Methods A total of 190 cases of CHF admitted in the hospital from April 2014 to January 2015 ,who were diagnosed as cardiac function IV by New York heart disease association (NYHA) ,were enrolled in the study .Follow-up was carried out for 6 months ,the primary endpoint was all-cause death ,and the secondary endpoint was hospitalization or death due to heart failure .The correlation between FT3 level at admission and prognosis in 6 months of CHF patients was analyzed .Results Patients were divided into 3 groups:FT3<3 .45 pmol/L (63 cases) ,3 .45 -4 .71 pmol/L (64 cases) and >4 .71 pmol/L (63 cases) according to the FT3 three percentile level at admission .The incidence of diabetes and the level of N terminal pro brain natriuretic peptide (NT-proBNP) in FT33 .45 -4 .71 pmol/L group were significantly lower than those in FT 3< 3 .45 pmol/L group and FT3> 4 .71 pmol/L group .Multiple factor COX regression analysis showed that FT 33 .45 -4 .71 pmol/L group (HR=0 .475 ,95％ CI:1 .181-4 .631 , P=0 .019) was an independent protective factor for all-cause of death .NT-proBNP (HR= 1 .516 ,95％ CI:1 .103-5 .443 ,P<0 .01) and diabetes (HR=2 .116 ,95％ CI:1 .218-5 .652 ,P=0 .021) were independent risk factors for all-cause of death ;33 .45 -4 .71 pmol/L group (HR= 0 .567 ,95％ CI:0 .198 -0 .896 ,P= 0 .023) was an independent protective factors for hospitalization due to aggravated heart failure or death due to heart failure .NT-proBNP (HR= 1 .643 ,95％ CI:1 .132 -5 .467 ,P< 0 .01) and diabetes (HR= 2 .253 ,95％ CI:1 .198-5 .451 ,P=0 .031) were independent risk factors for hospitalization due to aggravated heart failure or death due to heart failure .Conclusion Patients with severe CHF (FT33 .45-4 .71 pmol/L) have the lowest risk of all-cause death ,and the level of FT3 is also an independent protective factor for exacerbation of heart failure or death for heart failure .关键词
游离三碘甲状腺原氨酸/心力衰竭/全因死亡/慢性心力衰竭Key words
serum free triiodothyronine/heart failure/all-cause death/chronic heart failure分类
临床医学
