中南医学科学杂志2018，Vol.46Issue(3)：225-231,7.DOI:10.15972/j.cnki.43-1509/r.2018.03.001
环状RNA与心血管疾病
Circular RNA and cardiovascular diseases
摘要
Abstract
Circular RNA ( circRNA) is a class of RNA molecules shaped by a covalently closed continuous loop, it lacks the typical 5′cap and poly( A) tail. CircRNAs are abundent,stable,and specifically expressed in a cell type or tissue. Recent research indicates that the majority of circRNAs can serve as microRNA sponges, regulate gene expression andsplic-ing.Furthermore, circRNAs are able to bind with proteins mediating the translation of proteins.Emerging evidence supports that circRNAs play an important role in cardiovascular diseases. This study reviews the biosynthesis and function of circR-NAs, and also discusses the circRNA classification, feature and their potential significance in myocardial infarction,heart failure,atherosclerosis,as well as diabetic cardiomyopathy,providing a new strategyfor future diagnosis and therapy in cardi-ovascular diseases.关键词
环状RNA/心血管疾病/心血管系统Key words
circular RNAs/cardiovascular diseases/cardiovascular system分类
医药卫生引用本文复制引用
严若梦,胡长平..环状RNA与心血管疾病[J].中南医学科学杂志,2018,46(3):225-231,7.基金项目
国家自然科学基金(91439105,81473209). （91439105,81473209）
