日用化学工业2018，Vol.48Issue(3)：166-171,6.DOI:10.13218/j.cnki.csdc.2018.03.009
棕榈酰三肽-5皮肤美白功效及机制研究
Skin whitening efficacy and mechanism study of palmitoyl tripeptide-5
高雅倩 1唐健 1王志勇 2魏晓丽 3蔡亚3
作者信息
- 1. 无限极(中国)有限公司,广东 广州 510623
- 2. 上海医药工业研究院创新药物和制药工艺国家重点实验室,上海200437
- 3. 健土星生物技术研发(上海)有限公司,上海200335
- 折叠
摘要
Abstract
To evaluate skin whitening efficacy and mechanism of palmitoyl tripeptide-5,the cell viability was detected by MTT method,B16 guinea pig melanoma cell models treated by α-melanocyte stimulating hormone (α-MSH) and hyperpigment of UVB-stimulated dorsal skin of guinea pigs were measured.Activity of tyrosinase,the mRNA expression of MITF and tyrosinase were investigated.Results show that palmitoyl tripeptide-5 exert a skin whitening efficacy by inhibiting melanin production via downregulation of MITF and tyrosinase expression,inhibiting activity of tyrosinase in melanocytes.Colorimetric analysis shows that the palmitoyl tripeptide-5 significantly inhibit the pigmentation and reduce the gray value in UVB-irradiated guinea pig dorsal skin area (P ＜ 0.05).关键词
美白/棕榈酰三肽-5/紫外线/B16细胞/豚鼠Key words
whitening/palmitoyl tripeptide-5/UVB/B16 cell/guinea pig分类
化学化工引用本文复制引用
高雅倩,唐健,王志勇,魏晓丽,蔡亚..棕榈酰三肽-5皮肤美白功效及机制研究[J].日用化学工业,2018,48(3):166-171,6.
