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黄芪注射液治疗子宫内膜肿瘤临床疗效及对患者 肿瘤标志物血清CA125、HE4影响的研究

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陕西中医2018,Vol.39Issue(6):762-765,4.
陕西中医2018,Vol.39Issue(6):762-765,4.DOI:10.3969/j.issn.1000-7369.2018.06.024

黄芪注射液治疗子宫内膜肿瘤临床疗效及对患者 肿瘤标志物血清CA125、HE4影响的研究

Effect of Huangqi injection on the clinical effect of endometrial carcinoma and the effect of the serum CA125 and HE4 on the tumor markers

高歌1

作者信息

  • 1. 河南省平顶山市妇幼保健院妇产一科 平顶山 467000
  • 折叠

摘要

Abstract

Objective:To analyze the clinical efficacy of Huangqi injection in the treatment of endometrial cancer ,and the effects of serum tumor markers ,carcinoembryonic antigen 125 (CA125) and human epididymal se-cretory protein 4 (HE4) .Methods:124 cases of endometrial cancer admitted to our hospital were selected as the re-search subjects .All the patients did not conform to the indications of surgical treatment .They all received conserva-tive treatment .The patients were divided into two groups ,the control group and the observation group ,with 62 ca-ses in each group .The two groups of patients were treated with chemotherapy ,and the observation group was trea-ted with Huangqi injection on the basis of chemotherapy ,and the two groups all completed the established chemo-therapy scheme and course of treatment .Patients in two groups before and after chemotherapy ,the serum tumor markers CA125 ,HE4 ,T lymphocyte subsets two groups of patients after chemotherapy by response evaluation crite-ria in solid tumors (RECIST ) of the new low standard patients clinical curative effect judgment .the side effects of the two groups of patients with chemotherapy were collected and compared .Results:There was no significant differ-ence in serum CA125 ,HE4 ,CD3 + ,CD4 + ,CD8 + and CD4 + /CD8 + in the two groups before entering the group (P>0 .05) .After the treatment ,the patients in the observation group CA 125 ,HE4 decreased significantly ,CD3 + ,CD4 + , CD4 + and /CD8 + significantly increased (P< 0 .05) ,there was no significant difference between the two groups of patients before and after CD8 + treatment (P> 0 .05) .After the observation group completed the course of treatment ,the results of RECIST efficacy .The rate of PD in the observation group was significantly lower than that in the control group (P< 0 .05) .In the two groups of patients with chemotherapy ,the rate of side reaction in the observation group was significantly lower than that of the control group (P< 0 .05) .Conclusion:Huangqi injection adjuvant treatment of endometrial cancer patients can effectively promote the immune function , reduce the side effects of chemotherapy ,improve the effect of chemotherapy ,and has a high clinical mechanism for the treatment of endometrial cancer .

关键词

子宫内膜肿瘤/中西医结合疗法/生物标志物,肿瘤/@黄芪注射液

Key words

Endometrium/ integrated Chinese traditional and western medicine therapy/Biomarkers/tumor/@ Huangqi injection

分类

医药卫生

引用本文复制引用

高歌..黄芪注射液治疗子宫内膜肿瘤临床疗效及对患者 肿瘤标志物血清CA125、HE4影响的研究[J].陕西中医,2018,39(6):762-765,4.

基金项目

河南省重点科技攻关项目(132102423564) (132102423564)

陕西中医

OACSTPCD

1000-7369

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