陕西中医2018，Vol.39Issue(6)：800-805,6.DOI:10.3969/j.issn.1000-7369.2018.06.035
α-细辛脑脂质聚合物杂化纳米粒的制备及表征
Preparation and characterization of the lipid polymer hybrid nanoparticles loaded with α-Asarone
摘要
Abstract
Objective:To optimize the formulation of the lipid polymer hybrid nanoparticles loaded with α-Asa-rone ,and characterize its physical and chemical properties .Methods:ARE-LPHNPs was prepared by using self-as-sembly method ,four factors including the ratio of lecithin to mPEG-PLGA ,the mass of the mPEG-PLGA ,volume ratio of organic phase to aqueous phase and the ratio of drug to mPEG-PLGA were investigated ,then to optimize the preparation of ARE-LPHNPs by the central composite design response surface method ,and to study its physico-chemical properties .Result:The optimal process conditions of ARE-LPHNPs were as follows , the mass of the mPEG-PLGA was 4 .69 mg ,volume ratio of organic phase to aqueous phase was 1:2 .08 and the ratio of drug to mPEG-PLGA was 19 .74％ .According to the optimal conditions ,the morphological of ARE-LPHNPs was spherical in shape ,the mean diameter ,entrapment efficiency ,drug loading were(87 .67 ± 1 .25)nm ,(84 .17 ± 0 .37)％ 、(7 .63 ± 0 .05 )％ , respectively .Conclusion:ARE-LPHNPs was successfully prepared by self assembly method , the process is stable and easy to operate ,the morphology of nanoparticles is spherical ,and provide reference for the fur-ther development for the in vivo study .关键词
石菖蒲/中药开发/@α-细辛脑脂质聚合物Key words
Shichangpu/Development of Chinese materia medica/@ α-Asarum brain lipid polymer分类
医药卫生引用本文复制引用
蒋楠,穆珺,王春柳,张红,刘洋,马虎强,李晔..α-细辛脑脂质聚合物杂化纳米粒的制备及表征[J].陕西中医,2018,39(6):800-805,6.基金项目
西安市科技计划项目[(2017122SF/YX016(7)] （2017122SF/YX016(7）
