世界中医药2018，Vol.13Issue(5)：1063-1067,5.DOI:10.3969/j.issn.1673-7202.2018.05.005
冬夏季节变化对雄性金黄地鼠下丘脑-垂体-性腺轴功能影响的研究
Study on Effects of Seasonal Changes of Winter and Summer on the Function of Male Golden Hamster′s Hypothalamic-pituitary-gonad Axis
摘要
Abstract
Based on the "yin-yang of the four seasons and the five viscera" theory of TCM , this study systematically observed the effects of seasonal change of winter and summer on the hypothalamus -pituitary gonad axis function and the role of melatonin in this seasonal change , from the representative factors into the seasonal variation of illumination , to explore the scientific connotation of this theory.The content of MT, GnRH, LH, FSH, T in the plasma, hypothalamus, pituitary and testicular tissues of male golden hamster rats were detected , and the content of MR in various tissues were detected .The results showed that the content of GnRH in hypothalamus , LH and FSH in pituitary , T in testicular were characterized by high in summer and low in winter ( P<0.01 ) . Content of GnRH and T in plasma was high in summer and low in winter (P<0.01).FSH in plasma was higher in summer, but there was no statistically significant difference (P>0.05).Content of LH in plasma was higher in winter (P<0.05);Content of MT in plasma, the hypothalamus and testis were low in summer and high in winter (P<0.01);the content of MT and MR in the pituitary gland was higher in summer than winter (P<0.01).The content of MR in the hypothalamus and the testes was higher in winter ( P<0.01 or P<0.05 ) .Conclusion:The function of hypothalamic-pituitary-gonadal axis is characterized by seasonal changes in winter and summer , and MT may be involved in the regulation of this change , which can affect the secretion of gonado-tropin.The timely regulation of reproductive function suggests that there is indeed an adaptive variation law in coordination reso -nance between the body and the natural season .关键词
四时五藏阴阳/褪黑素/神经-内分泌/下丘脑-垂体-性腺轴/冬夏季节Key words
Yin-yang of the four seasons and the five viscera/Melatonin/Neuroendocrine/Hypothalamic-pituitary-gonad axis/Seasons of winter and summer分类
医药卫生引用本文复制引用
杨宗纯,韩俊阁,张娜,刘絮,刘晓燕,郭霞珍..冬夏季节变化对雄性金黄地鼠下丘脑-垂体-性腺轴功能影响的研究[J].世界中医药,2018,13(5):1063-1067,5.基金项目
国家自然科学基金项目(81573840) （81573840）
北京中医药薪火传承"3+3"工程程士德名家研究室 （）
