世界中医药2018，Vol.13Issue(5)：1076-1081,6.DOI:10.3969/j.issn.1673-7202.2018.05.007
对"四时五藏阴阳"理论生物学基础的探讨 ——时令季节对下丘脑-垂体-甲状腺轴功能节律的影响
Discussion on Biological Basis of"Yin-yang of the Four Seasons and the Five Viscera"——Effects of Seasons on the Functional Rhythm of Hypothalamic-Pituitary-Thyroid Axis
摘要
Abstract
Objective:To systematically observe the effects of seasonal changes on the function of the hypothalamus -pituitary-thy-roid (HPT) axis to verify the scientific connotation of the "yin-yang of the four seasons and the five viscera" theory.Methods:The contents of MT, TRH, TSH, T3, T4 in plasma and MT, MR, T3, and T4 in the thyroid tissue of male golden hamster were measured.Results:The results showed that the contents of MT, TRH, TSH, T3, and T4 in plasma showed the highest changes in winter, spring/autumn, and lowest in summer solstice.The contents of MT, MR, T3, and T4 in thyroid tissue showed the highest changes in summer solstice and lowest in autumn and winter .Conclusion:The function of HPT axis has obvious seasonal correla-tion, and its function is relatively enhanced in winter and spring .Melatonin may be a regulatory factor of this seasonal rhythm .The seasonal function change of HPT axis provides a biological basis for "yin-yang of the four seasons and the five viscera" theory.关键词
四时五藏阴阳/褪黑素/下丘脑-垂体-甲状腺/时令季节/肾应冬Key words
Yin-yang of the four seasons and the five viscera/Melatonin/Hypothalamus-pituitary-thyroid/Seasons/Kidney cor-responding with winter分类
医药卫生引用本文复制引用
韩俊阁,杨宗纯,张娜,刘絮,刘晓燕,袁涛,王效非,王素梅,郭霞珍..对"四时五藏阴阳"理论生物学基础的探讨 ——时令季节对下丘脑-垂体-甲状腺轴功能节律的影响[J].世界中医药,2018,13(5):1076-1081,6.基金项目
国家自然科学基金项目(81573840) （81573840）
北京中医药薪火传承"3+3"工程程士德名家研究室 （）
