世界中医药2018，Vol.13Issue(5)：1119-1122,4.DOI:10.3969/j.issn.1673-7202.2018.05.017
防己黄芪汤对乳腺癌术后水肿及免疫的影响
Effects of Fangji Huangqi Decoction on Edema and Immunity of Postoperative Breast Cancer
摘要
Abstract
Objective:To observe the clinical effect of Fangji Huangqi decoction on postoperative edema of breast cancer , and to evaluate the effects on the immunity of patients .Methods:A total of 60 patients with postoperative edema of breast cancer included into the research, were randomly divided into the control group (30 cases) and the observation group (30 cases).The patients of the control group had Furosemide , 20 mg/time, 1 time/day, oral furosemide, 20 mg/tablet, 1 time/day.The observation group had Fangji Huangqi decoction on the basis of control group , 200 mL warm-taken separately in the morning and evening , 1 agent/day, with continuous treatment for 14 d.Upper-arm circumference, FCAT-B+4 scale scores, clinical total effective rate, quality of life scores ( QOL) and the levels changes of CD 4 +, CD8 +, CD4 +/CD8 +, Th17, IL-17 of two groups before and after treat-ment were compared.Results:1) After treatment, the upper-arm circumference of the observation group was (19.28 ±1.12)cm. Compared with (33.12 ±2.53) cm of the control group, the differences were statistically significant (P<0.05, t=2.19).2) The clinical total effective rate of observation group was 86.67％, and that of control group was 66.66 ％.The differences were statistically significant (P<0.05, chi-square =3.14).3) FCAT-B+4 scale of the observation group graded (6.12 ±0.24) points, and the control group graded (8.02 ±1.01) points.The differences between the two groups had statistical significance (P<0.05, t=3.14).4) the QOL scores of the observation group was obviously higher than that of control group after treatment , and the differences were statistically significant (P<0.05).5) CD4 +and the ratio of CD4 +/CD8 +in the two groups were both higher than before treatment (P<0.05), and the content of CD8 +, Th17 and IL-17 levels was lower than that before treatment ( P<0.05 ) .The differences between the treatment group and control group were statistically significant ( P<0.05 ) .Conclu-sion:The Fangji Huangqi decoction could obviously improve postoperative edema of breast cancer , improve the quality of life in pa-tients with breast cancer , and the mechanism may be related to the improvement of the patients′immunity.关键词
乳腺癌/水肿/免疫/术后/防己黄芪汤/生命质量Key words
Postoperative breast cancer/Edema/Immunity/Postop/Fangji huangqi decoction/Quality of life分类
医药卫生引用本文复制引用
王伟,孔刘明,姜明强..防己黄芪汤对乳腺癌术后水肿及免疫的影响[J].世界中医药,2018,13(5):1119-1122,4.基金项目
2013年度河南省科技攻关计划项目(132102310230) （132102310230）
