世界中医药2018，Vol.13Issue(5)：1139-1142,1147,5.DOI:10.3969/j.issn.1673-7202.2018.05.022
痹祺胶囊对老年性膝关节炎的疗效及基质金属酶2/基质金属酶9表达的影响
Effects of Biqi Capsule on Knee Osteoarthritis and the Expression of Matrix Metalloenzyme 2/matrix metalloenzyme 9
摘要
Abstract
Objective:To observe the clinical efficacy of Biqi Capsule in the treatment of senile osteoarthritis of the knee .Meth-ods:From December 2015 to December 2017, 120 elderly patients with knee osteoarthritis were selected and randomly divided into the observation group and the control group , with 60 cases in each group .The control group was treated with intra articular injec-tion of sodium hyaluronate combined with oral Glucosamine Hydrochloride Capsules , and the observation group was treated with Bi Qi Capsule on the basis of it .Before and after treatment for five weeks , symptom score, quality of life scale SF-36, WOMAC scale and serum MMP-2 and MMP-9 of two groups were compared and evaluated , and the results were statistically analyzed .Results:After treatment , the total effective rate of the control group was 84.75％, and the total efficiency of observation group was 93.33％.Compared with before treatment , the symptom scores of two groups decreased significantly , and SF-36 increased ( P<0.05).The expression of WOMAC score in patients with serum MMP-2, MMP-9 were lower than those before treatment ( P<0.05), and the observation group was better than the control group (P<0.05).Conclusion:Biqi Capsule has good clinical effect on senile knee osteoarthritis .Its mechanism may be related to inhibiting the expression of MMP-2 and MMMP-9 in serum and de-creasing the degradation of cartilage matrix protein .关键词
痹祺胶囊/老年性膝关节炎/MMP-2/MMP-9/疗效/机制Key words
Biqi capsule/Knee osteoathritis/MMP-2/MMP-9/Effect/Mechanism分类
医药卫生引用本文复制引用
龚韶华,匡勇,郑煜新,石晓兵..痹祺胶囊对老年性膝关节炎的疗效及基质金属酶2/基质金属酶9表达的影响[J].世界中医药,2018,13(5):1139-1142,1147,5.基金项目
上海市宝山区中西医结合医院支持项目(ZY3-FWMS-2-1001)——膝痹病(膝骨性关节炎)综合诊疗服务模式的研究与实践 （ZY3-FWMS-2-1001）
