生物加工过程2018，Vol.16Issue(3)：41-46,6.DOI:10.3969/j.issn.1672-3678.2018.03.006
嘧啶结构骨架类抗疟药研究进展
Research progress of pyrimidine structural skeleton antimalarials
摘要
Abstract
Pyrimidine structural skeleton is one of the most important pharmacophore in the history of anti-malaria,which is widely concerned because it has a variety of pharmacological activities and is easier to synthesize and reform.In the recent years,some traditional antimalarial drugs have emerged in resistance. The effect of treatmenthas been significantly decreasing, so the modification of traditional antimalarial drugs has become imperative. In this paper, the recent novel pyrimidine skeleton compounds on antimalaria,such as benzopyrimidine, aminopyrimidine, quinoline pyrimidine and thiophene pyrimidine, are reviewed and this will provide some reference for the design of new antimalarial drugs.关键词
嘧啶结构骨架/抗疟药/构效关系Key words
pyrimidine structural skeleton/antimalarial drugs/structure-activity relationship分类
生物科学引用本文复制引用
丁奇峰,贺常虹,谈嘉怡,岳慧慧,薛蔹,于杨,黄和,黄菲..嘧啶结构骨架类抗疟药研究进展[J].生物加工过程,2018,16(3):41-46,6.基金项目
江苏省先进生物制造创新中心( XTE1810、XTC1850) （ XTE1810、XTC1850）
江苏高校优秀科技创新团队计划 （）
