陕西医学杂志2018，Vol.47Issue(6)：790-792,3.DOI:10.3969/j.issn.1000-7377.2018.06.032
乌司他丁辅助治疗70岁以上慢性阻塞性肺病急性加重期49例疗效及其对患者炎性因子影响研究
Efficacy of ulinastatin in the treatment of acute exacerbation of chronic obstructive pulmonary disease patients over 70 years of age and its influence on inflammatory factors and cellular immune function
柴春艳 1刘娅萍 1王甜 1杜洁 2徐邦强 1赵媛 1张粉利1
作者信息
- 1. 陕西省人民医院西院一病区 西安 710068
- 2. 陕西省人民医院健康体检中心 西安 710068
- 折叠
摘要
Abstract
Objective :To observe and explore the curative effect of ulinastatin (UTI) in the treatment of acute exacerbation of chronic obstructive pulmonary disease (AECOPD) patients over 70 years of age and its influence on peripheral blood inflammatory factors .Methods :98 AECOPD patients were enrolled in the study and randomly divid-ed into the treatment group(49cases) and the control group(49cases) .Two groups of patients were given the use of anti-infective ,phlegm ,foundation treatment ,the treatment group was added with UTI injection by micro pump ,200 , 000 IU each time ,twice a day for 7d .Their arterial blood gas analysis and peripheral blood inflammatory factors were examined and the clinical efficacy was evaluated .Results :7 days after the treatment ,the oxygenation index was (289 . 2 ± 25 .3 )in the treatment group ,which was significantly higher than that in the control group (251 .3 ± 20 .3) ,(P<0 .05) .The total effective rate was 89 .8％ in the treatment group ,which was higher than that in the control group (67 .3％ ,P< 0 .05) .The inflammatory factors in peripheral blood in the treatment group were significantly lower than that in the control group .Conclusion :AECOPD patients with early application of UTI injection can significantly decrease inflammatory response ,correct disorders of cellular immune function ,and improve therapeutic efficacy .关键词
肺疾病,慢性阻塞性/药物疗法/糖蛋白类/治疗应用/@乌司他丁注射液Key words
Pulmonary disease,chronic obstructive/drug therapy/Glycoproteins /therapeutic use/@ Uli-nastatin injection分类
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柴春艳,刘娅萍,王甜,杜洁,徐邦强,赵媛,张粉利..乌司他丁辅助治疗70岁以上慢性阻塞性肺病急性加重期49例疗效及其对患者炎性因子影响研究[J].陕西医学杂志,2018,47(6):790-792,3.
