眼科新进展2018，Vol.38Issue(6)：560-562,3.DOI:10.13389/j.cnki.rao.2018.0131
应用三维光学相干断层扫描仪对原发性开角型青光眼和正常眼脉络膜厚度的对比分析
Assessment of choroidal thickness in healthy and primary open-angle glaucoma eyes using deep-range imaging optical coherence tomography
摘要
Abstract
Objective To evaluate choroidal thickness (CT) in healthy and primary open-angle glaucoma (POAG) eyes using deep-range imaging optical coherence tomography (DRI-OCT) and to analyze the relationship between choroidal thickness and glaucoma.Methods Totally 140 patients (216 eyes) with POAG were selected as glaucoma group,and 67 patients (106 eyes) with normal eyes as normal group.The optical coherence tomography produced by Japanese company (Topcon) was used to detect CT in both groups.The association between CT and potential confounding variables including age,axial length,central corneal thickness,systolic pressure,diastolic pressure,systolic perfusion pressure,diastolic perfusion pressure,intraocular pressure,and visual field defects were examined by using univariable and multivariable regression analyses.Results The age,axial length,systolic blood pressure and systolic blood pressure of the glaucoma group were all higher than those of the normal group (all P ＜0.05),and the subjects in the glaucoma group had more severe visual field damage,and the difference of visual field defect was statistically significant (P ＜ 0.001).There was no significant difference in corneal thickness,diastolic blood pressure,intraocular pressure and diastolic perfusion pressure between the two groups (all P ＞ 0.05).The CT was (157.70 ± 48.54) μm in the glaucoma group,and (179.9 ± 36.1) μm in the normal group,respectively,and the difference was statistically significant (P ＜ 0.001).Uninitiated regression analysis showed that CT was negatively correlated with age,axial length and glaucoma (all P ＜ 0.05).Multivariate regression analysis showed that there was no significant difference in CT between glaucoma group and normal group when the length of the age and the axis of the eye were corrected (P =0.216),and moreover,there was also no association between glaucoma severity and CT.Conclusion Glaucoma is not associated with CT measured using DRI-OCT;however,older age and longer axial length were associated with thinner CT,so CT cannot be used as a marker for diagnosing POAG and assessing the condition of the disease.关键词
脉络膜厚度/原发性开角型青光眼/光学相干断层扫描Key words
choroidal thickness/primary open-angle glaucoma/optical coherence tomography分类
医药卫生引用本文复制引用
许海蒙,张春巍..应用三维光学相干断层扫描仪对原发性开角型青光眼和正常眼脉络膜厚度的对比分析[J].眼科新进展,2018,38(6):560-562,3.基金项目
黑龙江省留学归国科学基金项目(编号:LC2012C21) （编号:LC2012C21）
黑龙江省教育厅科学技术研究项目(编号:12511311) （编号:12511311）
哈尔滨市科技创新人才研究专项基金项目(编号:2011RFLYS029)Natural Science Foundation of Heilongjiang Province for Returned Scholars (No:LC2012C21) （编号:2011RFLYS029）
Scientific and Technical Research Fund of Education Bureau of Heilongjiang Province (No:12511311) （No:12511311）
Innovation Research Special Fund of the Science and Technology of Harbin of Heilongjiang Province (No:2011RFLYS029) （No:2011RFLYS029）
