Abstract
Objective To investigate the effect of minimally invasive drainage surgery on inflammatory mediators,cerebral hemorrhage markers in patients with hypertensive cerebral hemorrhage.Methods One hundred and twenty patients with hypertensive cerebral hemorrhage who were treated in department of neurosurgery of Chongzhou People's Hospital from February 2014 to February 2017 were selected.Patients were divided into the observation group (60 cases) and control group (60 cases).The patients of control group were treated with traditional craniotomy hematoma removal surgery,while the patients of observation group were treated with minimally invasive drilling drainage surgery.Compare the surgery,prognosis and the changes of inflammatory mediators,which including C reactive protein (CRP),neuron specific enolase (NSE),neurotrophic factor alpha (NTF-α),cerebral hemorrhage markers,which including N terminal pro brain natriuretic peptide (NT-proBNP),Granulocyte macrophage colony stimulating factor (GM-CSF),high mobility group boxin 1 (HMGB-1),neurological deficit score (NIHSS),Barthel index of two groups.Results In the operation time and length of stay,the observation group were significantly shorter than the control group (t =19.408,t =5.253,P =0.000,P =0.000),while in the re-bleeding rate,the difference between the two groups was not statistically significant (t =0.209,P =0.648).The patients of the observation group got a total effective rate of 91.7％,which was significantly better than the 76.7％ of the control group (x2 =5.065,P =0.024).The CRP,NSE and NTF-ot levels of the two groups were all significantly improved than before (t =29.153,t =20.936,t =4 2.223,t =20.712,t =15.7 83,t =22.046,P =0.000,P =0.000,P =0.000,P =0.000,P =0.000,P =0.000),and the patients of the observation group got more significant improvement (t =7.561,t =8.894,t =13.573,P =0.000,P =0.000,P =0.000).The NT-proBNP,GM CSF and HMGB 1 levels of the two groups were all significantly decreased than before (t =27.416,t =24.546,t =25.787,t =15.841,t =11.244,t =11.396,P =0.000,P =0.000,P =0.000,P =0.000,P =0.000,P =0.000),and the patients of the observation group got more significant decline (t =13.143,t =14.603,t =22.288,P =0.000,P =0.000,P =0.000).The NIHSS scores and Barthel index of the two groups were all significantly changed than before (t =20.091,t =12.243,t =16.537,t =9.160,P =0.000,P =0.000,P =0.000,P =0.000),and the patients of the observation group got more significant changes (t =12.386,t =7.189,P =0.000,P =0.000).Conclusion The effect of minimally invasive drilling drainage surgery in the treatment of elderly patients with hypertensive cerebral hemorrhage is good,it can significantly improve neurological function and inflammation,reduce cerebral hemorrhage markers levels,which is contribute to the prognosis of patients and worthy of promotion.关键词
高血压/脑出血/微创钻孔引流术/炎性介质/神经功能/老年人Key words
Hypertensive cerebral hemorrhage/Minimally invasive drilling drainage surgery/Inflammatory mediators/Neurological function/Elderly
