Abstract
Objective To investigate the relationship between blood pH,blood glucose,myocardial enzymes and amylase in patients with diabetic ketoacidosis,and to provide a reference for the clinical diagnosis and treatment of diabetic ketoacidosis patients.Methods The clinical data of 135 diabetic patients with diabetic ketoacidosis admitted from February 2016 to September 2017 in our hospital were retrospectively analyzed.According to their severity,the patients were divided into mild,moderate and severe groups with 45 cases in each group.The changes of blood pH and blood glucose level were observed in three groups of patients.The changes of blood amylase,lipids and myocardial enzymes were compared among the three groups.Spearman correlation analysis was used to analyze the correlation between blood pH,blood glucose,myocardial enzymes and amylase.Results With diabetic ketoacidosis patients' condition aggravate,their blood pH value gradually decreased,blood glucose levels gradually increased;The levels of TG,serum amylase,CPK and AST in severe group and moderate group were significantly higher than those in mild group (severe group:t =5.419,P ＜ 0.01,t =4.089,P ＜ 0.01,t =11.285,P＜0.01,t=3.181,P＜0.001;moderate group:t =2.441,P ＜0.008,t =2.273,P＜0.013,t=7.644,P＜0.01,t =2.325,P ＜ 0.011),TC levels were significantly lower than those in the mild group (severe group:t =3.635,P ＜0.000;moderate group:t =1.758,P ＜ 0.041);serum TG,CPK,CPK-MB,LDH,AST and serum amylase gradually increased high,TC level gradually decreased.There was a positive correlation between blood pH and TC,AST and LDH (r =0.418,P=0.018;r=0.432,P=0.012;r=0.454,P=0.002,r=-0.425,P=0.013).There was a negative correlation between blood glucose and TC,AST and LDH (r =-0.405,P =0.028;r =0.418,P =0.010).There was a positive correlation with TG level (r =0.436,P =0.012).There was no correlation between pH value and blood glucose level with CPK-MB and CPK.The blood pH value of patients with diabetic ketoacidosis is negatively correlated with the level of serum amylase,LDH and AST,and there is a positive correlation between the blood glucose level and the level of serum amylase,LDH and AST in patients with diabetic ketoacidosis.关键词
糖尿病酮症酸中毒/血pH/血糖/心肌酶/淀粉酶Key words
Diabetic ketoacidosis/Blood pH/Blood glucose/Myocardial enzymes/Amylase
