中国临床医学2018，Vol.25Issue(1)：5-8,4.DOI:10.12025/j.issn.1008-6358.2018.20170880
基于单中心经导管主动脉瓣置换术治疗主动脉瓣狭窄初步临床疗效分析
Clinical efficacy of transcatheter aortic valve replacement in treatment of patients with aortic valve stenosis based in a single Chinese center
摘要
Abstract
Objective:To evaluate the safety and efficacy of transcatheter aortic valve replacement (TAVR) in 40 patients with aortic valve stenosis in our center.Methods:Totally 40 consecutive patients who underwent TAVR in our center were enrolled.The endpoints included success rate of operation,complications,follow-up results 30 days after operation,etc.Results:There were 27 males and 13 females with mean age of (78.3±5.0) years old.The success rate of operation was 100 ％.After operation,the mean aortic valve pressure gradient decreased significantly ([10.77 ± 3.90] rnmHg vs [61.80± 18.62] mmHg,P＜0.001),while the mean flap area increased significantly ([1.80 ± 0.24] cm2 vs [0.65 ± 0.17] cm2,P＜ 0.001).The NYHA class was significantly improved (1.80±0.62 vs 2.95±0.75,P＜0.001) after TAVR.One day after operation,there were 13 with paravalvular regurgitation (12 of mild cases and 1 of moderate case),1 with acute occlusion of right coronary artery,1 with valve dislodgement then ischemic stroke,and 1 with intractable pericardial effusion and pericardial tamponade.In the 30-day follow-up,the mortality rate was 2.5 ％ (1 patient) and the incidence of permanent cardiac pacemaker for abnormal cardiac conduction was 10％ (4 patients).Conclusions:TAVR is safe and effective for aortic stenosis patients with high-risk or surgical contradication in our country.关键词
主动脉瓣狭窄/经导管主动脉瓣置换术/瓣周漏Key words
aortic valve stenosis/transcatheter aortic valve replacement/paravalvular regurgitation分类
医药卫生引用本文复制引用
李明飞,潘文志,张蕾,张晓春,周达新,葛均波..基于单中心经导管主动脉瓣置换术治疗主动脉瓣狭窄初步临床疗效分析[J].中国临床医学,2018,25(1):5-8,4.基金项目
上海市科委产学研项目子课题(14DZ1941500),上海市科委科技创新行动计划生物医药领域科技支撑项目(16441908100).Supported by Sub-Project of Shanghai Science and Technology Commission Production Research (14DZ1941500),Biomedical Science and Technology Support Project of Scientific and Technological Innovation Plan in Shanghai Science and Technology Commission (16441908100). （14DZ1941500）
