中国临床医学2018，Vol.25Issue(1)：9-12,4.DOI:10.12025/j.issn.1008-6358.2018.20170935
肝内胆管细胞癌中E3泛素化连接酶UHRF2的表达及临床意义
Expression of E3 ubiquitin ligase UHRF2 in intrahepatic cholangiocarcinoma and its clinical significance
摘要
Abstract
Objective:To explore the expression and clinical significance of ubiquitin-like with PHID and ring finger domains 2 (UHRF2) in intrahepatic cholangiocarcinoma (ICC).Methods:The expression of UHRF2 in 138 ICC was determined by immunohistochemistry,and the relationships between UHRF2 expression with prognosis and clinicopathological features of ICC were analyzed:Results:UHRF2 was highly expressed in ICC compared with paratumorous tissues.Level of UHRF2 was associated with high AFP level (P=0.010),poor tunor differentiation (P=0.026),lymph node metastasis (P=0.001),and advanced TNM stage (P=0.019).Hevated UHRF2 expression was suggested to be associated with poor prognosis and high recurrence rate in ICC patients (P＜ 0.001),and multivariable analysis indicated that UHRF2 was of theprognostic indicators of ICC (P＜0.05).Conclusions:High level of UHRF2 is related to the malignant phenotype of ICC,and can be a prognostic and recurrent indicator of postoperative patients.关键词
UHRF2/肝内胆管细胞癌/预后Key words
UHRF2/intrahepatic cholangiocarcinoma/prognosis分类
医药卫生引用本文复制引用
曾海英,彭睿,黄晓勇,张歆昱,杨轩,陆佳成,施国明,柯爱武,蔡加彬..肝内胆管细胞癌中E3泛素化连接酶UHRF2的表达及临床意义[J].中国临床医学,2018,25(1):9-12,4.基金项目
国家自然科学基金(81502526,81602513,81672825).Supported by National Natural Science Foundation of China(81502526,81602513,81672825). （81502526,81602513,81672825）
