中国临床医学2018，Vol.25Issue(1)：27-30,4.DOI:10.12025/j.issn.1008-6358.2018.20171132
乳腺特异性伽马成像半定量指标与乳腺癌临床特征的相关性
Correlation between semi-quantitative index in breast specific gamma imaging and clinical features in patients with breast cancer
摘要
Abstract
Objective:To analyze the correlations of semi-quantitative index,tumor to non lesion ratio (T/N)in breast specific gamma imaging (BSGI) and clinical features in breast cancer.Methods:Totally 668 patients who underwent BSGI from January 2016 to July 2017 were enrolled.BSGI interpretation was assessed based on visual spectrum analysis and semi-quantitative analysis.The value of T/N in craniocaudal (CC) and mediolateral oblique(MLO) view was respectively obtained and the maximum value was selected for semi-quantitative analysis.Then the T/N value was compared among different pathological status.Results:Among 668 cases,there were 505 of malignant mass and 163 of benign mass,and the T/N value was obtained in all the cases.Analysis of receiver operating characteristic curve (ROC) showed that the sensitivity and specificity in diagnosing breast cancer was 84.53％ and 74.02％,respectively,taking critical value of T/N as 1.81,and the AUC was 0.83 (SD=0.844,95％ CI 0.812-0.872).The T/N value was significantly different among patients with different tumor size (P=0.000),Ki-67 expression (P=0.039) and axillary lymph node metastases (P=0.02).Conclusions:The T/N value in BSGI is correlated with tumor size,Ki-67 expression,and axillary lymph node metastases,which can be used in predicting aggressiveness of breast cancer.关键词
乳腺特异性伽马成像/乳腺癌/99mTc-MIBIKey words
breast specific gamma imaging/breast cancer/99mTc-MIBI分类
医药卫生引用本文复制引用
倪小健,马晶晶,张宏伟,朱玮..乳腺特异性伽马成像半定量指标与乳腺癌临床特征的相关性[J].中国临床医学,2018,25(1):27-30,4.基金项目
国家自然科学基金(81702586,81502267),复旦大学附属中山医院青年基金(2016ZSQN59).Supported by National Natural Science Foundation of China (81702586,81502267) and the Fund for Young Scholar of Zhongshan Hospital,Fudan University (2016ZSQN59). （81702586,81502267）
