中国临床医学2018，Vol.25Issue(1)：31-34,4.DOI:10.12025/j.issn.1008-6358.2018.20170998
18F-FDG PET/CT最大标准摄取值与中低分化肝细胞肝癌临床病理特征的相关性
Correlations between maximum standardized uptake value in 18F-FDG PET/CT and clinical pathological characteristics of moderately to poorly differentiated hepatocellular carcinoma
摘要
Abstract
Objective:To investigate the correlations between the maximum standardized uptake value (SUVmax) in fluorodeoxyglucose F18 (18F-FDG) positron emission tomography-computed tomography (PET/CT) with the tumor differentiation,tumor size,and Ki-67 expression in patients with moderately and poorly differentiated hepatocellular carcinoma (HCC).Methods:The 18F-FDG PET/CT imaging data of 187 patients with single HCC lesion confirmed by pathology were evaluated retrospectively.According to the differentiation degree of tumor pathology,the patients were divided into moderate differentiation group,moderate-poor differentiation group,and poor differentiation group.According to the maximum diameter of the tumor,the patients were divided into ≤3 cm,3-5 cm,5-10 cm,and ＞10 cm group.According to the positive rate of Ki-67 expression,the patients were divided into high expression group (++,+++,and ++++) and low expression group (-and +).The SUVmax of primary tumor and the tumor to normal background ratio (TNR) were compared among groups.Furthermore,the correlations between SUVmax and pathological characteristics of HCC such as the maximum diameter of the tumor,tumor differentiation,and Ki 67 expression were analyzed.Results:The SUVmax and TNR were significantly different among moderate differentiation group (n =98),moderate-poor differentiation group (n =52) and poor differentiation group (n=37,both P＜0.000 1),and the SUVmax was significantly correlated with the differentiation degree of tumor cells (r=-0.384 57,P＜0.000 1).The maximum tumor diameter ≤3 cm group (n=70),3 5 cm group (n=51),5-10 cm group (n=43),and ＞10 cm group (n=23) had significant differences in SUVmax and TNR (both P＜0.000 1),and the SUVmax was significantly correlated with the maximum tumor diameter (r=0.537 27,P＜0.000 1).The SUVmax and TNR were both significantly different between Ki-67 low expression group (n=102) and Ki-67 high expression group (n=85,both P＜ 0.000 1),and the SUVmax was significantly correlated with the expression of Ki-67 (r=0.370 96,P＜0.000 1).Conclusions:In patients with moderately to poorly differentiated HCC,the SUVmax and TNR in 18FFDG PET/CT are significantly associated with poor differentiation,large tumor size,and high expression of Ki* 67.关键词
肝细胞肝癌/正电子发射断层显像计算机体层摄影术/18F-氟脱氧葡萄糖Key words
hepatocellular carcinoma/positron emission tomography-computed tomography/fluorodeoxyglucose F18分类
医药卫生引用本文复制引用
张一秋,李蓓蕾,银武,陈曙光,石洪成..18F-FDG PET/CT最大标准摄取值与中低分化肝细胞肝癌临床病理特征的相关性[J].中国临床医学,2018,25(1):31-34,4.基金项目
上海市卫生和计划生育委员会科研课题面上项目(201440539).Supported by Research Program of Shanghai Municipal Commission of Health and Family Planning (201440539). （201440539）
