中国临床医学2018，Vol.25Issue(1)：56-60,5.DOI:10.12025/j.issn.1008-6358.2018.20170205
C4d联合外周血抗体对移植肾患者预后的预测价值
Predictive value of C4d combined with HLA antibody and MⅠCA antibody on prognosis of renal transplantation patients
张明 1顾勇 1陆福明 1瞿连喜 2何军 3袁晓妮3
作者信息
- 1. 复旦大学附属华山医院肾脏科,上海200040
- 2. 复旦大学附属华山医院泌尿外科,上海200040
- 3. 苏州大学附属第一医院,江苏省血液研究所,苏州215006
- 折叠
摘要
Abstract
Objective:To investigate the relationships of C4d,HLA antibody,and MⅠCA antibody with renal pathology.Methods:Totally 52 patients with complete pathological data were included and followed up for one year.The C4d was stained with indirect immunofluorescence,the levels of HLA antibody and MⅠCA antibody in peripheral blood were detected by Luminex method.The relationships of C4d with antibodies in peripheral blood and pathology of renal graft were analyzed,and their influences on renal function were exposed.Results:The positive rate of HLA antibody was 88.9 ％ in cases with positive C4d and 40％ in the cases with negative C4d.The positive rate of HLA antibody was higher in patients with positive C4d than that in patients with negative C4d(P=0.003).The proportion of glomerulitis was higher in cases with positive C4d (P=0.023),and vasculitis and arterial intimal thickening of transplanted renal were more common in cases with positive HLA antibody than those with negative HLA antibody (P＜0.05),while no correlations between histological features and MⅠCA antibody were found.There was no difference in glomerular filtration rate (GFR) between cases with positive and negative C4d,but in patients of positive C4d with positive HLA antibody or MⅠCA antibody,the GFR decreased more remarkably compared with those of single positive C4d (P＜0.05).Conclusions:For patients of acute rejection,positive C4d combined with positive antibodies of HLA and MⅠCA in peripheral blood has better predictive value for graft survival compared with single positive C4d.关键词
肾移植/HLA抗体/MⅠCA抗体/急性排异/C4dKey words
renal transplantation/HLA antibody/MⅠCA antibody/acute rejection/C4d分类
医药卫生引用本文复制引用
张明,顾勇,陆福明,瞿连喜,何军,袁晓妮..C4d联合外周血抗体对移植肾患者预后的预测价值[J].中国临床医学,2018,25(1):56-60,5.
