中国临床医学2018，Vol.25Issue(1)：103-107,5.DOI:10.12025/j.issn.1008-6358.2018.20170926
PI3K/Akt信号通路在肝脏缺血再灌注损伤中的研究进展
Research progresses of PI3K/Akt signaling pathway in hepatic ischemia-reperfusion injury
摘要
Abstract
Liver ischemia-reperfusion injury is the leading cause of delayed recovery of liver function and dysfunction after operation.Some studies have shown that PI3K/Akt signaling pathway is activated during ischemia and reperfusion,which plays a protective role on the liver by inhibiting or enhancing the expressions of downstream target proteins.Therefore,PI3K/ Akt signaling has become an important target pathway for preventing and improving hepatic ischemia-reperfusion injury.This review summarized the research progresses of PI3K/Akt signaling pathway in hepatic ischemia-reperfusion injury.关键词
PI3K/Akt/缺血再灌注损伤/炎症反应/氧化应激/细胞凋亡/自噬Key words
PI3K/Akt/ischemia-reperfusion injury/inflammatory response/oxidative stress/apoptosis/autophagy分类
医药卫生引用本文复制引用
陈勇,付贞,范林,熊艳,叶啟发,秦伟..PI3K/Akt信号通路在肝脏缺血再灌注损伤中的研究进展[J].中国临床医学,2018,25(1):103-107,5.基金项目
国家自然科学基金新疆联合项目(U1403222).Supported by Xinjiang Joint Project of National Natural Science Foundation of China(U1403222). （U1403222）
