中国现代医学杂志2018，Vol.28Issue(15)：7-11,5.DOI:10.3969/j.issn.1005-8982.2018.15.002
依达拉奉对矽肺大鼠的干预治疗作用研究
Protective effect of Edaravone on rat of pneumosilicosis
摘要
Abstract
Objective To investigate the protective effect of Edaravone on pulmonary fibrosis in rat of penumosilicosis. Methods Rat model of pneumosilicosis was established by daily intratracheal instillation of silica in suspension (250 mg/kg) for consecutive 28 days. Edaravone was intraperitoneally injected on a daily basis at 4 ml/kg. Saline was administrated in control group. Tissues as well as organs were harvested at 7 d, 14 d, 21 d and 28 d. Hematoxylin eosin staining was performed for histological changes of lung tissue. Level of TGF-β was identified by Western blot. Concentration of HYP, GSH and MDA was measured by commercial kits. Results Edaravone significantly ameliorated pulmonary fibrosis when compared with that in penumosilicosis group, improving GSH activity and reducing the levels of HYP, TGF-β and MDA. Conclusions Edaravone exerts therapeutic effect for silicosis by reducing free radical and TGF-β expression.关键词
矽肺/依达拉奉/自由基/转化生长因子βKey words
silicosis/Edaravone/free radical/TGF-β分类
医药卫生引用本文复制引用
肖漪,彭子荷,孙悦,刘嘉祺,王路,郭灵丽,郝小惠,刘和亮,王宏丽..依达拉奉对矽肺大鼠的干预治疗作用研究[J].中国现代医学杂志,2018,28(15):7-11,5.基金项目
国家自然科学基金(No:81673119) （No:81673119）
唐山市国际科技合作项目(No:14160201B) （No:14160201B）
唐山市科技创新团队培养计划项目(No:15130212C) （No:15130212C）
