中国现代医学杂志2018，Vol.28Issue(15)：88-91,4.DOI:10.3969/j.issn.1005-8982.2018.15.019
两种检测HAV-IgM试剂的敏感性评价
Sensitivity of two immunoassays for detection of Hepatitis A Virus immunoglobulin M
张海莹 1王震宇 1孔祥沙 1季颖 1朱凌 1魏来1
作者信息
- 1. 北京大学人民医院 北京大学肝病研究所(丙型肝炎和肝病免疫治疗北京市重点实验室),北京 100044
- 折叠
摘要
Abstract
Absract: Objective To evaluate the sensitivity of two immunoassay kits for anti-Hepatitis A Virus (HAV) IgM.Method On the gold standard confirmed by assay-Abbott HAV-IgM, the sensitivity of the two kits for testing HAVIgM in China were evaluated. The correlation of S/CO value of the two kits with Abbott HAV-IgM were estimated.Results HAV IgM had a sensitivity and specificity of 94.3％ and 85.2％ respectively with Wantai test, while 97.1％ and 91.3％ respectively with Gaoda test. HAV-IgM (Abbott) showed a correlation of S/CO valuewith HAV-IgM (Wantai) test and HAV-IgM (Gaoda) test, respectively (r = 0.597 and 0.541, all P = 0.000). HAV-IgM (Wantai) test and HAV-IgM (Gaoda) test showed good consistency with HAV-IgM (Abbott) test, with a k-coefficients of 0.648 and 0.772, respectively. Conclusion HAV-IgM (Wantai) and HAV-IgM (Gaoda) have good detection performances,which provides important reference for clinical detection and seroepidemiology statistics.关键词
甲型肝炎病毒/IgM/敏感性/一致性Key words
hepatitis A virus/IgM/sensitivity/concordance rate分类
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张海莹,王震宇,孔祥沙,季颖,朱凌,魏来..两种检测HAV-IgM试剂的敏感性评价[J].中国现代医学杂志,2018,28(15):88-91,4.
