中国现代医学杂志2018，Vol.28Issue(16)：29-33,5.DOI:10.3969/j.issn.1005-8982.2018.16.006
聚乙二醇和聚丙烯酸钠对纳米碳酸钙口服制剂的改性评估研究
Research on oral agent of nano calcium carbonate modified by PEG and PAAS
摘要
Abstract
Objective To modify the spherical nanometer calcium carbonate by polyethylene glycol (PEG) and sodium polyacrylate (PAAS), and analyze its effect on intestinal lead removalin vitro. Methods The spherical nanometer calcium carbonate was made by the method of compound decomposition, and it surface properties were modified by dispersant PEG and PAAS. The structural characteristics of the modified nanometer calcium carbonate were investigated by the analysis of particle size and zeta potential, scanning electron microscopy, transmission electron microscopy, X-ray powder diffraction method and infrared spectrum. The effect of lead removal from the simulated intestinal fluidin vitro was measured by atomic absorption spectrometer. Results The particle size, electric potential, dispersion and crystal stability of the modified nanometer calcium carbonate were the best when the ratio of PEG to PAAS was 1 : 1, and the lead ion concentration was reduced to below 30 μg/L in 4 h, with satisfactory effect of lead removal. The difference was significant compared with micron calcium carbonate (P < 0.05). Conclusions The calcium carbonate nanoparticles modified by PEG and PAAS are stable and non-toxic, and can be further made into oral preparation for removing lead from human intestinal tract.关键词
纳米碳酸钙/聚乙二醇/聚丙烯酸钠/除铅/铅中毒Key words
nanometer calcium carbonate/polyethylene glycol/sodium polyacrylate/lead removal/lead poisoning分类
医药卫生引用本文复制引用
廖明媚,王成志,肖平,赵劲风,潘一峰..聚乙二醇和聚丙烯酸钠对纳米碳酸钙口服制剂的改性评估研究[J].中国现代医学杂志,2018,28(16):29-33,5.基金项目
国家国际科技合作专项项目(No:2013DFA31440) （No:2013DFA31440）
