中国循证儿科杂志2018，Vol.13Issue(2)：113-117,5.DOI:10.3969/j.issn.1673-5501.2018.02.007
亲缘单倍体非体外去除T细胞的造血干细胞移植和同胞全相合移植治疗儿童急性白血病的临床研究
A clinical study of haploidentical and matched sibling donor hematopoietic stem cell transplantation without in vitro T-cell depletion for the treatment of acute leukemia in pediatric patients
摘要
Abstract
Objective To investigate the clinical outcome of haploidentical hematopoietic stem cell transplantation without in vitro T-cell depletion for children with acute leukemia.Methods In Beijing Children's Hospital,Capital Medical University,from June 8,2007 to May 4,2015,23 children with acute leukemia had been treated with haploidentical related hematopoietic stem cell transplantation without in vitro T-cell depletion,and 21 children with acute leukemia had been treated with matched sibling donor hematopoietic stem cell transplantation.Both groups used myeloablative preconditioning regime,and G-CSF mobilized hematopoietic stem cell.Graft versus host disease (GVHD) prophylaxis consisted of cyclosporine A,methotrexate with or without mycophenolate mofetil.To prevent hepatic vein occlusion disease (VOD),prostaglandin E combined with or without low molecular weight heparin was used.Results All patients attained hematopoietic stem cell transplantation successfully.The median time of leukocyte recovery for haploidentical group and matched sibling group were (13.1 ±2.3) days and (12.5 ± 1.4) days,respectively(P＞0.05).The median time of platelet recovery for haploidentical group and matched sibling group were (19.4 ± 8.0) days and (22.8 ± 7.7) days,respectively (P＞0.05).The median follow-up time was (49.6 ± 30.3) months and (32.5 ± 31.6) months after transplantation,the overall survival rates were 69.5％ (16/23) vs71.4％ (15/21),the difference was not statistically significant (P＞0.05).Acute GVHD clinical grading (Ⅰ ～ Ⅳ) was 65.2％ (15/23) in haploidentical group and 23.8％ (5/21) in matched sibling group,and the difference was statistically significant (P＜0.05).Conclusion It can be achieved the same clinical effect of haploidentical related hematopoietic stem cell transplantation without in vitro T-cell depletion in the treatment of children with leukemia,compared with matched sibling hematopoietic stem cell transplantation.The safety and efficacies of haploidentical group were close to the matched sibling group.关键词
单倍体/非体外去除T细胞/造血干细胞移植/白血病/儿童Key words
Haploidentical/Without in vitro T-cell depletion/Hematopoietic stem cell transplantation/Leukemia/Pediatric引用本文复制引用
穆艳顺,秦茂权,郑胡镛,王彬,李斯丹,朱光华,杨骏,周翾,王凯,闫岩,林巍..亲缘单倍体非体外去除T细胞的造血干细胞移植和同胞全相合移植治疗儿童急性白血病的临床研究[J].中国循证儿科杂志,2018,13(2):113-117,5.基金项目
北京市医院管理局临床医学发展专项经费资助:ZY201404 （）
北京市医院管理局登峰计划:DFL2015110 （）
首都卫生发展科研专项-重点攻关:首发2016-1-2091 （）
