中国药房2018，Vol.29Issue(10)：1312-1319,8.DOI:10.6039/j.issn.1001-0408.2018.10.05
基于系统药理学的茵陈作用机制研究
Study on the Mechanism of Artemisia capillaries Based on Systems Pharmacology
摘要
Abstract
OBJECTIVE:To investigate the possible mechanism of Artemisia capillaries,and to provide reference for further development and utilization of it. METHODS:The effective components and related target protein of A. capillaries were screened by Traditional Chinese Medicine Systems Pharmacology (TCMSP) analysis platform database. The effective compound-target protein visual network of A. capillaries was established by using Cytoscape 3.5.1 software,topology analysis was also performed. The protein-protein interaction (PPI) network was constructed and analyzed by STRING database. KEGG pathway enrichment of target protein coding gene was analyzed by DAVID bioinformatics resource database. RESULTS:A total of 13 kinds of effective compounds,189 target proteins and 34 enrichment pathways were selected. Quercetin,β-glutamol,isorhamnetin and artepillin C were main effective compounds. Prostaglandin G/H sythase 2(PTGS 2),heat shock protein 90(HSP 90),dipeptidyl peptidase Ⅳ, protein kinase A catalytic subunit Cα were main target proteins. Transcription factor AP-1 and cell tumor antigen p53 played a key role in PPI network. The target protein coding gene was rich in TNF-α signaling pathway,HIF-1 signaling pathway,Toll-like receptor signaling pathway,PI3K/Akt signaling pathway,T cell receptor signaling pathway,thyroid hormone signaling pathway, apoptotic signaling pathway,etc. CONCLUSIONS:Quercetin,β-glutamol and isorhamnetin of A. capillaries play an effect on PTGS2,HSP90,transcription factor AP-1 and other target proteins through TNF-α signaling pathway,HIF-1 signaling pathway and PI3K/Akt signaling pathway,so as to play anti-inflammatory and antitumor effect.关键词
系统药理学/茵陈/有效化合物/靶标蛋白/信号通路/药理作用Key words
Systems pharmacology/Artemisia capillaries/Effective compound/Target protein/Signaling pathway/Pharmacological effect分类
医药卫生引用本文复制引用
陈国铭,许华,汤顺莉,邝梓君,黄雁,赵金龙,於菁雯,陈子茵,林洪荣,黄楚瑶..基于系统药理学的茵陈作用机制研究[J].中国药房,2018,29(10):1312-1319,8.基金项目
国家自然科学基金资助项目(No.81373686) （No.81373686）
