中国药房2018，Vol.29Issue(10)：1395-1400,6.DOI:10.6039/j.issn.1001-0408.2018.10.25
艾司西酞普兰与度洛西汀治疗抑郁症有效性与安全性的Meta分析
Effectiveness and Safety of Escitalopram and Duloxetine in the Treatment of Depression:a Meta-analysis
摘要
Abstract
OBJECTIVE:To systematically evaluate the effectiveness and safety of escitalopram and duloxetine in the treatment of depression, and provide evidence-based reference for clinical treatment. METHODS:Retrieved from PubMed, Wanfang database,VIP,CNKI and CBM,randomized controlled trials (RCTs) about escitalopram (trial group) and duloxetine (control group) in the treatment of depression were collected. Meta-analysis was conducted by using Rev Man 5.3 software after data extraction and quality evaluation according to bias risk assessment tool recommended by system evaluator manual 5.3. RESULTS:Finally 25 RCTs were included,involving 2621 patients. The results of Meta-analysis showed that there was no statistical significance in total response rate between 2 groups after 1,2,4,6,8 weeks of treatment or cure rate between 2 groupsafter 4,6,8 weeks of treatment (P>0.05). There was no statistical significance in total response rate [RR=0.96,95％CI(0.88, 1.05),P=0.42] or cure rate [RR=0.91,95％CI(0.78,1.06),P=0.24] of female patients,as well as total response rate [RR=0.96, 95％CI(0.84,1.11),P=0.61] or cure rate [RR=0.90,95％CI(0.54,1.49),P=0.69] of elderly patients between 2 groups. The incidence of constipation [RR=0.59,95％CI (0.42,0.81),P=0.001],dry mouth [RR=0.65,95％CI(0.51,0.82),P=0.0004], nausea [RR=0.68,95％CI(0.56,0.83),P=0.0002] and decreased appetite [RR=0.74,95％CI(0.55,0.99),P=0.04] in trial group were significantly lower than control group,with statistical significance. CONCLUSIONS:The effectiveness of escitalopram is similar to duloxetine in the treatment of depression,but the safety of escitalopram is better than duloxetine.关键词
艾司西酞普兰/度洛西汀/抑郁症/有效性/安全性/Meta分析Key words
Escitalopram/Duloxetine/Depression/Effectiveness/Safety/Meta-analysis分类
医药卫生引用本文复制引用
路淑淑,李文馨,张贝贝,李智强,靳英辉,侯宁..艾司西酞普兰与度洛西汀治疗抑郁症有效性与安全性的Meta分析[J].中国药房,2018,29(10):1395-1400,6.基金项目
国家自然科学基金资助项目(No.81603496) （No.81603496）
