中国药理学通报2018，Vol.34Issue(6)：741-744,4.DOI:10.3969/j.issn.1001-1978.2018.06.001
黄酮类化合物的心血管保护作用机制研究进展
Research advances in cardiovascular protective effects of flavonoids
摘要
Abstract
Flavonoids are a large class of bioactive compounds widely found in food and plants. Studies have found that they have a good preventive and therapeutic effect on cardiovascular diseases. Flavonoids have a wide range of pharmacological effects, including antioxidation, anti-inflammation, vasodila-tion, inhibiting platelet aggregation and regulating blood lipids and so on. The cardiovascular protective mechanism of fla-vonoids involves the enzymes that inhibit the production of oxy-gen derived free radicals, inhibition of lipid peroxidation and in-flammatory factor, down-regulation of epoxy synthase activity and activation of AMPK and nuclear factor kappa B signaling pathway. In this review we summarize the so far acquired knowl-edge of the most important mechanisms of flavonoid action, so as to provide the theoretical basis for the research and development of the active monomers in flavonoid and compound preparations.关键词
黄酮类化合物/心血管保护/机制/抗氧化/抗炎/血管舒张Key words
flavonoids/cardiovascular disease/mechanism/antioxidation/anti-inflammation/vasodilation分类
医药卫生引用本文复制引用
李旭光,方莲花,杜冠华..黄酮类化合物的心血管保护作用机制研究进展[J].中国药理学通报,2018,34(6):741-744,4.基金项目
国家自然科学基金资助项目(No 81573645,81603101) （No 81573645,81603101）
中国医学科学院医学与健康科技创新工程项目( No 2017-I2M-1-010) （ No 2017-I2M-1-010）
