中国药理学通报2018，Vol.34Issue(6)：745-749,5.DOI:10.3969/j.issn.1001-1978.2018.06.002
铁死亡在肝细胞癌中的作用以及研究进展
Research progress in role and mechanism of ferroptosis in hepatocellular carcinoma
摘要
Abstract
Hepatocellular carcinoma ( HCC) is the most com-mon primary liver cancer resulted from various etiological fac-tors, among which HBV infection is the most important reason in China. The development and progression of HCC are regulated by a variety of cytokines and intracellular signaling pathways. In recent years, both clinical and basic studies have shown that fer-roptosis plays an important role in the occurrence of HCC. Fer-roptosis can affect the development of liver diseases by regulating the level of intracellular iron and lipid peroxidation. Many schol-ars believe that ferroptosis can be used as a target for the diagno-sis, prevention and treatment of HCC. In this review, the role of ferroptosis in HCC and its research progress has been summa-rized, including ferroptosis summary, the relationship between ferroptosis and HCC, and the molecular mechanisms of ferropto-sis in HCC.关键词
铁死亡/肝细胞癌/作用机制/信号通路/铁离子/脂质过氧化Key words
ferroptosis/hepatocellular carcinoma/mechanism/signal pathways/iron/lipid peroxidation分类
医药卫生引用本文复制引用
王玲,贾岩,李蒙蒙,王飞虾,张自力,张峰,郑仕中..铁死亡在肝细胞癌中的作用以及研究进展[J].中国药理学通报,2018,34(6):745-749,5.基金项目
国家自然科学基金资助项目( No 31571455,31401210, 31600653,81600483,81270514) （ No 31571455,31401210, 31600653,81600483,81270514）
江苏省自然科学基金青年基金项目( No BK20140955 ) （ No BK20140955 ）
江苏省中药药效与安全性评价重点实验室开放课题( No JKLPSE 201502 ) （ No JKLPSE 201502 ）
江苏高校优势学科建设工程资助项目( PAPD) （ PAPD）
