中国药理学通报2018，Vol.34Issue(6)：753-756,4.DOI:10.3969/j.issn.1001-1978.2018.06.004
线粒体ATP敏感钾通道与心血管疾病
Mitochondrial ATP-sensitive potassium channels and cardiovascular diseases
摘要
Abstract
With the aging of population and the changes of lifes-tyle, the cardiovascular diseases have become a serious threat to human health. Meanwhile, the cardiovascular death has become the chief death reason during recent epidemiological survey, so the prevention and treatment of cardiovascular diseases have be-come the focus of researches now. Mitochondrial ATP-sensitive potassium channels ( mitoKATP ) is an inward rectifier potassium channel located in the mitochondrial inner membrane, which has the effect of improving the energy metabolism, inhibiting the ap-optosis, relieving the overload of Ca2+ and stabilizing the inter-nal environment. Recently, some researchers have also found that mitoKATP can influence the development of cardiovascular diseases in different ways. This paper summarizes the structure and function of mitoKATP and the relationship between cardiovas-cular diseases and mitoKATP , aiming to clarify its role in the de-velopment of cardiovascular diseases.关键词
心血管疾病/线粒体ATP敏感钾通道/能量代谢/心功能不全/心律失常/糖尿病心肌病Key words
cardiovascular diseases/mitochondrial ATP-sensi-tive potassium channels/energy metabolism/cardiac failure/ar-rhythmia/diabetic cardiomyopathy分类
医药卫生引用本文复制引用
段鹏,王金鑫,卫世强,段玉慧,朱庆磊..线粒体ATP敏感钾通道与心血管疾病[J].中国药理学通报,2018,34(6):753-756,4.基金项目
国家自然科学基金资助项目(No 81570349) （No 81570349）
