中国药理学通报2018，Vol.34Issue(6)：756-759,4.DOI:10.3969/j.issn.1001-1978.2018.06.005
外泌体源性RNAs在中枢神经系统中的研究进展
Research progress on role of exosomes-shuttle-RNAs within central nervous system
摘要
Abstract
Exosomes are nanoscale vesicles produced and secre-ted into extracellular fluid by all cells. They mediate cell com-munication through carrying and transferring informational car-goes ( proteins, nucleic acids, lipids and so on ) to recipient cells. In central nervous system, exosomes can be released from all cell types including neurons, neural stem cells and neuroglia cells. These exosomes shuttle nucleic acids ( miRNAs, mRNAs and so on) and play an important role in nervous system devel-opment and function as well as diseases including Alzheimer's disease and drug addiction. Furthermore, the functional effects and targeting characteristics of exosomes-shuttle-RNAs suggest that exosomes-shuttle-RNAs can be diagnostic and therapeutic targets. In this review, we elaborate the effects, functions and mechanisms of exosomes-shuttle-RNAs in order to gain a new recognition of CNS development and diseases.关键词
外泌体/RNAs/miRNAs/核酸/中枢神经系统/细胞通讯Key words
exosomes/RNAs/miRNAs/RNAs/central nerv-ous system/cell communication分类
医药卫生引用本文复制引用
区锦莹,李婵,李汉成,周玉婷,罗超华,莫志贤..外泌体源性RNAs在中枢神经系统中的研究进展[J].中国药理学通报,2018,34(6):756-759,4.基金项目
国家自然科学基金资助项目(No 81673628, 81229003) （No 81673628, 81229003）
广州市科技计划项目(No 20170710287) （No 20170710287）
