中国药理学通报2018，Vol.34Issue(6)：770-775,6.DOI:10.3969/j.issn.1001-1978.2018.06.008
西红花提取物对局灶型脑缺血/再灌注大鼠线粒体分裂融合的影响
Effect of extraction of saffron crocus on mitochondrial dynamics in ischemia/reperfusion rats
摘要
Abstract
Aim To investigate the protection mecha-nism of the extraction of the saffron crocus in ischemia/reperfusion rats. Methods Hematoxylin-eosin stai-ning, electron microscopy, and neurological assess-ments were performed in a transient middle cerebral ar-tery occlusion ( tMCAO ) rat model. The role of dy-namin-related protein 1 ( Drp1 ) and optic atrophy 1 ( Opa1 ) , the two key regulators of mitochondrial fis-sion and fusion in ischemic brain damage in vivo were observed. Results In ischemia/reperfusion rats, the extraction of the saffron crocus increased the level of protein Opa1 and decreased the level of protein Drp1 . Conclusions Inhibition of Drp1 and promotion of Opa1 , which means to maintain balancing mitochondri-al dynamics, is proposed as an efficient strategy for neuroprotection against ischemic brain damage.关键词
西红花/脑缺血/神经元/线粒体分裂融合/Drp1/Opa1Key words
saffron crocus/ischemia/reperfusion/neuron/mitochondria fission/fusion/Drp1/Opa1分类
医药卫生引用本文复制引用
张业昊,姚明江,丛伟红,刘建勋..西红花提取物对局灶型脑缺血/再灌注大鼠线粒体分裂融合的影响[J].中国药理学通报,2018,34(6):770-775,6.基金项目
国家重点基础研究发展计划( 973 计划)资助项目( No 2015CB554405) （ 973 计划）
