中国药理学通报2018，Vol.34Issue(6)：836-840,5.DOI:10.3969/j.issn.1001-1978.2018.06.019
黄芪多糖对抑郁大鼠海马NF-κB信号通路的影响
Effects of astragalus polysaccharide on hippocampal NF-κB signaling in rats with depressive behaviors
摘要
Abstract
Aim To investigate the effects of astragalus polysaccharide ( APS ) on depressive behaviors and hippocampal NF-κB signaling in rats with depression. Methods Wistar rats were randomly divided into con-trol group, depressive group, APS-low (200 mg·kg-1 ·d-1 ) group and APS-high ( 400 mg · kg-1 · d-1 ) group. Depressive behaviors were induced by chronic unpredictable mild stress ( CUMS) in rats. After trea-ted with APS, depressive behaviors were valuated by open field test, forced swim test and sucrose preference test. Levels of NF-κB p65, phosphorylated NF-κB p65 ( p-NF-κB p65 ) , phosphorylated IκBα ( p-IκBα) , NF-κB p65 DNA binding activity, TNF-α, IL-1β and IL-6 were measured to assess the activity of NF-κB sig-naling pathways. Results Compared to control group, rats in depressive group had less sucrose intake in su-crose preference and longer immobility time in forced swim test, as well as increased hippocampal NF-κB signaling activity. However, APS treatment dose-de-pendently alleviated depressive-like behaviors and in-hibited the activation of NF-κB signaling induced by UCMS. Conclusion The antidepressant effects of APS might be associated with the inhibition of hipp-ocampal NF-κB signaling pathway.关键词
黄芪多糖/抑郁/海马/NF-κB通路/TNF-α/IL-1β/IL-6Key words
APS/depression/hippocampus/NF-κB signaling/TNF-α/IL-1β/IL-6分类
医药卫生引用本文复制引用
王煜,李承德,曲敬蓉,李浩,陈博超,聂克,毛淑梅..黄芪多糖对抑郁大鼠海马NF-κB信号通路的影响[J].中国药理学通报,2018,34(6):836-840,5.基金项目
国家自然科学基金资助项目( No 81673779 ) （ No 81673779 ）
山东省自然科学基金资助项目( No ZR2011HL066, ZR2013CM033, ZR2015CL029) （ No ZR2011HL066, ZR2013CM033, ZR2015CL029）
山东省教育厅科技计划项目 ( No J15LL54,J16LM11) （ No J15LL54,J16LM11）
山东省中医药管理局项目( No 2013-242,2015-237) （ No 2013-242,2015-237）
