中国肿瘤生物治疗杂志2018，Vol.25Issue(4)：329-333,5.DOI:10.3872/j.issn.1007-385x.2018.04.002
上皮-间质转化和多形性成胶质细胞瘤的侵袭性
Epithelial-interstitial transformation and invasion of glioblastoma multiforme
摘要
Abstract
Glioblastoma multiforme (GBM) is the most common malignant tumor of the central nervous system.Despite advances in traditional treatment strategies that combine surgery with radiotherapy and chemotherapy,GBM remains one of the most lethal diseases with dismal prognosis.Epithelial-interstitial transformation (EMT) is an important biological process for the invasion and migration of malignant tumors derived from epithelial cells,which is closely related to the pathological behaviors of GBM including invasion,migration,resistance to chemotherapy and radiotherapy.This review will introduce the concept of EMT and its pathophysiological process,especially the latest findings related to the GBM biology.Besides,gene regulation and signaling pathways of EMT (such as matrix metalloproteinases [MMP],TGF-β,transcription factors Snail and Twist etc.) participated in GBM are also introduced,thereby providing a new insight into the fundamental researches and clinical treatments of GBM.关键词
多形性成胶质细胞瘤/上皮间质转化/金属基质蛋白酶Key words
glioblastoma multiforme/epithelial-interstitial transformation/matrix metalloproteinases分类
医药卫生引用本文复制引用
仇波,王运杰..上皮-间质转化和多形性成胶质细胞瘤的侵袭性[J].中国肿瘤生物治疗杂志,2018,25(4):329-333,5.基金项目
国家十三五计划科技支撑计划课题子课题资助项目(No.2016YFC1301800).Project supported by the Sub-Project of National Sci-Tech Support Thirteenth Five-Year Plan of China (No.2016YFC1301800) （No.2016YFC1301800）
