中国肿瘤生物治疗杂志2018，Vol.25Issue(4)：370-375,6.DOI:10.3872/j.issn.1007-385x.2018.04.009
lncRNA ANRIL在胶质瘤组织中的表达及其临床意义
Expression and clinical significance of lncRNA ANRIL in glioma tissues
费帆 1何永生 1王友于 2李梦妮 3何森4
作者信息
- 1. 四川省医学科学院四川省人民医院神经外科,四川成都610072
- 2. 四川省医学科学院四川省人民医院胸外科,四川成都610072
- 3. 四川省医学科学院四川省人民医院儿科,四川成都610072
- 4. 遵义医学院研究生院,贵州遵义563003
- 折叠
摘要
Abstract
Objective:To investigate the expression and clinical significance of lncRNA ANRIL in glioma tissues.Methods:129 cases of glioma tissues and 25 cases of normal brain tissues as control were collected from patients treated in Sichuan Provincial People's Hospital from January 01,2012 to December 30,2016.Real-time quantitative PCR was used to detect the mRNA expression of lncRNA ANRIL;and the relationship between lncRNA ANRIL expression and sensitivity of patients to temozolomide as well as the clinical prognosis of glioma patients were analyzed.Results:Compared with control group,the expression of lncRNA ANRIL in 129 cases of glioma tissues was significantly increased ([8.730±0.336] vs [1.090±0.137],t=9.957,P＜0.01).The expression of lncRNA ANRIL in WHO Ⅰ-Ⅱ grade patients was significantly lower than that of patients at grade Ⅲ-Ⅳ ([4.198±0.260] vs [10.550±0.291],t=13.03,P＜ 0.01).lncRNA ANRIL expression was significantly correlated with WHO stage,the sensitivity to temozolomide (TMZ) and survival status (all P＜0.05),but not associated with gender,age,KPS score and tumor size (all P＞0.05).Moreover,Kaplan-Meier analysis demonstrated that decreased lncRNA ANRIL expression contributed to significantly longer overall survival ([29.17±0.64] vs [13.54±0.74] months,P＜0.01) and recurrence-free survival time ([9.08±0.56] vs [15.88±0.83] months,P＜0.01).Univariate and multivariate analysis also indicated that lncRNA ANRIL expression,WHO stage and chemosensitivity could be independent prognostic markers for glioma (P＜0.05).Conclusion:Higher pathological grade of glioma patients indicates higher lncRNA ANRIL expression and shorter survival time.lncRNA ANRIL is involved in the occurrence and development of glioma,and can be used as a molecular marker for the diagnosis and prognosis of glioma.关键词
lncRNA ANRIL/胶质瘤/预后/标志物Key words
lncRNA ANRIL/glioma/prognosis/marker分类
医药卫生引用本文复制引用
费帆,何永生,王友于,李梦妮,何森..lncRNA ANRIL在胶质瘤组织中的表达及其临床意义[J].中国肿瘤生物治疗杂志,2018,25(4):370-375,6.
