中国卒中杂志2018，Vol.13Issue(5)：455-462,8.DOI:10.3969/j.issn.1673-5765.2018.05.009
颅内外动脉粥样硬化相关因素的差异
Differences in Related Factors of Intracranial and Extracranial Atherosclerosis
摘要
Abstract
Objective To explore the differences in Related factors between intracranial and extracranial atherosclerosis. Methods From the Chinese Intracranial Atherosclerosis Study (CICAS), all the enrolled patients were divided into four groups: no significant intracranial or extracranial atherosclerosis group, only intracranial atherosclerosis group, only extracranial atherosclerosis group, and intracranial and extracranial atherosclerosis group. With no significant intracranial or extracranial atherosclerosis group as control, the logistic regression analysis was used to assess the possible factors associatedwith intracranial or extracranial atherosclerosis.Results Of 2864 patients, 1388 (48.5%) had no significant intracranial or extracranial atherosclerosis,1074 (37.5%) had only intracranial atherosclerosis, 141 (4.9%) had only extracranial atherosclerosis,and 261 (9.1%) had intracranial and extracranial atherosclerosis. Multi-factors analysis showed thatindependent factors associated with intracranial atherosclerosis were white matter lesions [odds ratio(OR) 1.359, 95% confidence interval (CI) 1.109-1.666, P =0.0031], leukocyte count (OR 1.045, 95%CI1.007-1.084, P =0.0210), fasting blood glucose (OR 1.054, 95%CI 1.009-1.101, P =0.0182), and highdensity lipoprotein (OR 0.644, 95%CI 0.480-0.864, P =0.0034); Independent factors associated withextracranial atherosclerosis were senior age (OR 1.047, 95%CI 1.026-1.069, P <0.0001), smoking(OR 1.887, 95%CI 1.212-2.937, P =0.0050), previous history of ischemic cerebrovascular disease (OR2.260, 95%CI 1.352-3.778, P =0.0019), and leukoaraiosis (OR 0.603, 95%CI 0.394-0.922, P =0.0196).Senior age (OR 1.022, 95%CI 1.006-1.039, P =0.0064), diabetes mellitus (OR 1.494, 95%CI 1.053-2.118, P =0.0244) and family history of stroke (OR 1.964, 95%CI 1.302-2.961, P =0.013) were theindependent factors of intracranial and extracranial atherosclerosis. Hyperhomocysteinemia was acommon independent factor in the three groups.Conclusion The related factors may have differences between intracranial and extracranialatherosclerotic lesions. Leucocyte count, fasting blood glucose, and high-density lipoprotein areassociated with intracranial atherosclerotic lesions; while age, smoking and history of ischemiccerebrovascular disease are associated with extracranial atherosclerosis. Hyperhomocysteinemia isthe common independent factor of intra-and extracranial lesions.关键词
缺血性卒中/颅内动脉粥样硬化/相关因素/危险因素Key words
Ischemic stroke/Intracranial atherosclerosis/Related factor/Risk factor引用本文复制引用
濮月华,黄家星,王拥军,刘丽萍,邹昕颖,王伊龙,潘岳松,向祥龙,苏霭欣,梁慧康,赵性泉,王春雪..颅内外动脉粥样硬化相关因素的差异[J].中国卒中杂志,2018,13(5):455-462,8.基金项目
北京市科技新星计划(Z161100004916104) （Z161100004916104）
