中国卒中杂志2018，Vol.13Issue(5)：463-468,6.DOI:10.3969/j.issn.1673-5765.2018.05.010
亚低温联合丁基苯酞对溶栓时间窗外急性大脑中动脉闭塞患者预后的影响
Effect of Mild Hypothermia Combined with Dl-3n-butyphthalide on Prognosis in Patients with Acute Middle Cerebral Artery Occlusion beyond Thrombolysis Time
摘要
Abstract
Objective To investigate the effect of mild hypothermia (MHT) combined with dl-3n-butyphthalide (NBP) on collateral circulation and short-term prognosis of patients with acute middle cerebral artery occlusion (MCAO) and progressive motor deficit (PMD) beyond thrombolysis time. Methods Patients with acute MCAO and PMD beyond thrombolysis time were recruited consecutively. They were randomized into the conventional treatment group, the MHT group and the MHT+NBP group. The parameters between the three groups, including baseline clinical data, the Fugl-Meyer motor function scores at Day 14, collateral circulation, the National Institute of Health Stroke Scale (NIHSS) scores, the hemorrhagic transformation, the anterior communicating artery (ACoA), the posterior communicating artery (PCoA), the ipsilateral and contralateral systolic peak flow velocity ratio of anterior cerebral artery (RVaca) and posterior cerebral artery (RVpca), the modified Rankin scale (mRS) scores at Day 90, the rate of mortality at Day 90, were compared. Results A total of 69 patients having completed follow-up were recruited in the study, including 23 in the conventional treatment group, 21 in the MHT group, and 25 in the MHT+NBP group. The Fugl-Meyer motor function scores at Day 14, the anterior communicating artery (ACoA), the posterior communicating artery (PCoA), RVaca, RVpca in the MHT+NBP group were respectively higher than that in the MHT group and conventional treatment group (all P<0.05). The NIHSS scores at Day 14, the mRS scores at Day 90 in the MHT+NBP group were respectively lower than that in the MHT group and CT group (all P<0.05). The hemorrhagic transformation at Day 14 in the MHT+NBP group was lower than in the conventional treatment group (P<0.05). The RVaca at Day 14, and the mRS scores at Day 90 in the MHT group were lower than that in the conventional treatment group (all P<0.05). There were no significant difference in 90-day mortality rate among the three groups. Conclusion MHT combined with NBP could improve collateral circulation and short-term prognosis in patients with acute MCAO and PMD beyond thrombolysis time.关键词
亚低温/丁基苯酞/大脑中动脉闭塞/脑侧支循环/进展性运动功能缺损Key words
Mild hypothermia/Dl-3n-butyphthalide/Middle cerebral artery occlusion/Cerebral collateral circulation/Progressive motor deficit引用本文复制引用
刘炫君,王强,杨国帅,林海丽,周艳辉,程启慧,周律,张艳君,胡裕洁,郝海珍..亚低温联合丁基苯酞对溶栓时间窗外急性大脑中动脉闭塞患者预后的影响[J].中国卒中杂志,2018,13(5):463-468,6.基金项目
海南省自然科学基金项目(20158272)海口市重点科技计划(2014-073) （20158272）
