动物营养学报2018，Vol.30Issue(2)：476-483,8.DOI:10.3969/j.issn.1006-267x.2018.02.010
霉菌毒素对肠道黏蛋白的影响及其作用机制
Effects of Mycotoxins on Intestinal Mucins and Its Action Mechanism
摘要
Abstract
Mycotoxins are secondary metabolites produced by fungi in the field of cereal growth,harvest and storage or processing which is widely found in feed ingredients and human food.Mycotoxins not only reduce the quality of feed,but also seriously damage the health of animals,reduce animal production performance;its residues in animal products have a serious threat to human health.A large number of studies have shown that mycotoxins can damage the intestinal mucosal barrier,affecting the composition of intestinal flora,regulate intestinal immune response,induced intestinal lesions and finally causing intestinal inflammation.The mucins secreted by intestinal goblet cells,the main component of the mucus layer function as the intestine innate immune first defense line.Intestinal mucins play an important role in maintaining the dynamic balance of the intestinal mucosa and regulating the microbial-host immune response.The effects of mycotoxins on intestinal mucins and underlying mechanism were reviewed in this paper,which provided a theoretical basis for further researches in this field.关键词
霉菌毒素/肠道黏蛋白/肠道黏膜损伤/调控机制Key words
mycotoxins/intestinal mucins/intestinal inflammation/regulation mechanism分类
农业科技引用本文复制引用
黄鑫,高亚男,王加启,郑楠..霉菌毒素对肠道黏蛋白的影响及其作用机制[J].动物营养学报,2018,30(2):476-483,8.基金项目
国家自然科学基金资助项目(31501399) （31501399）
国家重点基础研究发展计划(2011CB100805) （2011CB100805）
现代农业产业技术体系专项资金(nycytx-04-01) （nycytx-04-01）
中国农业科学院科技创新工程(ASTIP-IAS12) （ASTIP-IAS12）
