摘要
Abstract
Objective To evaluate the influence of central precocious puberty (CPP) on lung function of girls .Methods From January 2015 to December 2017 ,24 girls diagnosed with CPP in Ningbo Women's and Children's Hospital were selected as CPP group , and then 24 cases of healthy girls were selected as control group in same period .Physical development was evaluated ,and forced expiratory volume in one second (FEV1) ,forced vital capacity (FVC) ,FEV1/FVC ,peak expiratory flow rate (PEF) ,maximal mid-expiratory flow (MMEF) and exhaled nitric oxide (FeNO) were measured for analysis .Results The height of CPP group was lesser than that of control group ,and uterine length ,weight ,BMI were higher (t value was 3 .037 ,5 .582 and 4 .905 ,respectively , all P < 0 .05) .Two cases (8 .33% ) complained of significant increased FEV1 after stimulation in CPP group (increasing 16 .4% and 17 .3% ,respectively) ,while FeNO ,FEV1 before and after stimulation ,FVC ,PEF and MMEF before stimulation of CPP group were lower than control group (t value ranged 2 .064 - 6 .472 ,all P < 0 .05) .Uterine length was negatively correlated with FEV 1/FVC and MMEF after stimulation (r value was - 0 .581 and - 0 .473 ,respectively ,both P < 0 .05) ,and diagnosis age of CPP was also negatively correlated with FEV 1 before and after stimulation (r value was - 0 .493 and - 0 .512 ,respectively ,both P < 0 .05) . Conclusion CPP girls still have lung function decreased and airway hyperresponsiveness after GnRH treatment .关键词
中枢性性早熟/女童/肺功能/相关性Key words
central precocious puberty (CPP)/girls/lung function/correlation分类
医药卫生
