中国妇幼健康研究2018，Vol.29Issue(6)：713-716,4.DOI:10.3969/j.issn.1673-5293.2018.06.009
RNA结合蛋白QKI-5、Ezrin在浆液性卵巢癌中的研究
Expressions of RNA-binding proteins QKI-5 and Ezrin in serous ovarian carcinoma
朱士杰 1施正祥2
作者信息
- 1. 浙江大学舟山医院妇产科,浙江 舟山 316000
- 2. 浙江大学舟山医院神经内科 ,浙江 舟山 316000
- 折叠
摘要
Abstract
Objective To detect the expressions of RNA-binding proteins QKI-5 and Ezrin in serous ovarian carcinoma and to explore their correlation with the occurrence and development of serous ovarian carcinoma .Methods Forty patients with serous ovarian carcinoma diagnosed in Zhoushan Hospital of Zhejiang University from 2012 to 2017 and 20 normal women were enrolled in this study .Expressions of RNA-binding proteins QKI-5 and Ezrin in ovarian tissue samples were detected by immunohistochemistry , results were analyzed ,and correlation between them was explored .Results Expressions of QKI-5 mRNA and Ezrin in ovarian tissue in serous ovarian carcinoma patients were significantly down-regulated when compared with those in normal controls , and differences were statistically significant (t value was 2 .71 and 3 .72 ,respectively ,both P < 0 .05) .Ezrin positive rate in serous ovarian carcinoma patients was 97 .50% ,while positive rate of Ezrin in ovarian epithelial cells in normal controls was 100 .00% . There was no significant difference between two groups (χ2 = 0 .51 ,P = 0 .48) .Conclusion Down-regulation of expressions of RNA binding-proteins QKI-5 and Ezrin is closely related to pathological process such as tumor occurrence and development in serous ovarian cancer patients ,so these two indicators are expected to be early diagnostic indexes for ovarian cancer ,and they provide new ideas for clinical treatment of ovarian cancer patients .关键词
RNA结合蛋白/QKI-5/Ezrin/浆液性卵巢癌Key words
RNA-binding protein/QKI-5/Ezrin/serous ovarian cancer分类
医药卫生引用本文复制引用
朱士杰,施正祥..RNA结合蛋白QKI-5、Ezrin在浆液性卵巢癌中的研究[J].中国妇幼健康研究,2018,29(6):713-716,4.
