摘要
Abstract
Objective To investigate the efficacy of escitalopram combined with rational emotive therapy on patients with postpartum depression and to provide theoretical basis for combination treatment of medication and psychotherapy for postpartum depression .Methods Clinical data of 60 patients with postpartum depression hospitalized in Second People 's Hospital of Zhoushan from June 2015 to June 2017 were analyzed retrospectively .Patients were divided into observation group and control group according to different treatment methods .Patients in control group received conventional treatment with escitalopram , while patients in observation group received rational emotive therapy on basis of therapeutic schedule for the control group .Depression was evaluated by Hamilton Depression Scale (HAMD) before treatment and at 1 week ,1 month ,3 months ,and 6 months after treatment ,and clinical efficacy was assessed .Quality of life before and after treatment was investigated by using MOS item short from health survey (SF - 36) .Results Total effective rate in the observation group was 86 .67% ,which was significantly higher than that of 60 .00% in the control group (χ2 = 5 .455 ,P < 0 .05) .There was significant difference in HAMD scores before and after treatment in both groups (F value was 43 .562 and 43 .562 ,respectively ,both P < 0 .05) ,and with extension of treatment ,HAMD scores decreased gradually in both groups .HAMD scores at 1 week ,1 month ,3 and 6 months after treatment in the observation group were significantly lower than those in the control group (t value was 6 .875 ,7 .237 ,7 .875 and 6 .065 ,respectively ,all P < 0 .05) . Intra group comparison showed that social function ,physiological function ,general health ,physical function ,emotional function , mental health ,vigor score ,body pain scores of SF-36 scale after treatment in both groups were significantly higher than those before treatment (t value ranged 4 .265 to 9 .961 ,all P < 0 .05) .However ,comparison between groups showed that scores of social function ,physiological function ,general health ,physical function ,emotional function ,mental health and vigor score in SF-36 scale after treatment in the observation group were significantly higher than those in the control group (t value was 6 .764 ,5 .875 , 7 .452 ,4 .054 ,5 .765 ,6 .986 and 8 .054 ,respectively ,all P < 0 .05) .There was no significant difference in somatic pain score after treatment between two groups ( t = 1 .213 ,P > 0 .05 ) .Conclusion Escitalopram combined with rational emotive therapy can effectively reduce depression of patients with postpartum depression .It has better curative effect and can greatly improve quality of life .关键词
艾司西酞普兰片/理性情绪疗法/产后抑郁症/SF-36量表/汉密顿抑郁量表Key words
escitalopram/rational emotive therapy/postpartum depression/SF - 36 scale/Hamilton Depression Scale (HAMD)分类
医药卫生
