国际生殖健康/计划生育杂志2018，Vol.37Issue(3)：243-246,4.
慢性炎症与多囊卵巢综合征的关系及相关研究进展
Chronic Inflammation in Pathogenesis of Polycystic Ovary Syndrome and Research Progress
摘要
Abstract
Polycystic ovary syndromes (PCOS),a common endocrine disorder in women of puberty and childbearing age,is characterized by ovulation disorder,insulin resistance (IR) and hyperandrogenemia (HA).It is one of the main causes of female infertility.Chronic inflammation is an important way of defense for the body.However,it is also one of the causes of metabolic diseases.Patients with PCOS have chronic and low-grade inflammation,because the levels of some inflammatory factors were abnormally increased in those patients.More and more evidences have suggested the close relationship between chronic inflammation and the pathogenesis of PCOS,although there is still some controversy.Many inflammatory factors were secreted during the pathophysiological duration of PCOS,which causes the chronic low-grade inflammation.New evidences suggested that chronic inflammation may be actually involved in obese,IR and HA in the early stage of PCOS.Some antiinflammatory drugs have been used to improve the inflammatory microenvironment of PCOS in the clinical practice,with a definite effect.In this paper,the relationship between chronic inflammation and the pathogenesis of PCOS,as well as the research progress was reviewed.关键词
多囊卵巢综合征/胰岛素抗药性/治疗/慢性炎症/高雄激素血症Key words
Polycystic ovary syndrome/Insulin resistance/Therapy/Chronic inflammation/Hyperandrogenemia引用本文复制引用
李子涵,张宁,张建霞..慢性炎症与多囊卵巢综合征的关系及相关研究进展[J].国际生殖健康/计划生育杂志,2018,37(3):243-246,4.基金项目
山东省自然科学基金(ZR2017BH062) （ZR2017BH062）
山东省重点研发计划项目(2017GSF19107) （2017GSF19107）
