广西医学2018，Vol.40Issue(10)：1125-1128,4.DOI:10.11675/j.issn.0253-4304.2018.10.02
二代杂交捕获技术联合液基细胞学检测在宫颈高级别 上皮内瘤变患者冷刀锥型切除术后随访中的应用价值
Application value of hybrid captureⅡ technique and Thinprep cytologic test in follow-up after cold knife conization in patients with high-grade cervical intraepithelial neoplasia
摘要
Abstract
Objective To explore the application value of hybrid captureⅡtechnique( HCⅡ) combined with Thinprep cytologic test(TCT) in the follow-up after cold knife conization(CKC) in the patients with high-grade cervical intraepithelial neoplasia(CINⅡ-Ⅲ). Methods A total of 228 patients pathologically confirmed as CINⅡ-Ⅲafter CKC were enrolled. At the 3 ,6,9 ,12 and 18 months after CKC,HCⅡand TCT were conducted during the follow-up, and a cervical pathohistological examination was performed in patients with positive results. The pathological results were taken as gold standard,then the efficiencies of HCⅡ,TCT,and HCⅡ/TCT co-test for diagnosing the recrudescence of lesions were analyzed. Results Of 228 patients, recrudescence existed in 27 patients after cervical conization. The sensitivities of HCⅡ,TCT,and HCⅡ/TCT co-test for diagnosing the recrudescence of lesions in the patients with CINⅡ-Ⅲ after CKC were 92. 6％,70. 4％ and 100. 0％ respectively,the specificities were 97. 5％,96. 5％ and 96. 5％ respectively,the positive predictive values were 83. 3％,73. 1％ and 79. 4％ respectively,the negative predictive values were 99. 0％,96. 0％ and 100. 0％ respectively,and the areas under receiver operating characteristic curve were 0. 951,0. 853 and 0. 983 respectively. The sensitivity,negative predictive value and area under the curve of HCⅡ/TCT co-test were higher or larger than those of TCT(all P<0. 05),but no statistically significant differences were found in those indices above between HCⅡ/TCT co-test and HCⅡ,or between HCⅡ and TCT(all P>0. 05). Conclusion The combined detection of HCⅡand TCT can improve the diagnostic sensitivity and negative predictive value for the recrudescence of lesions. It obtains a higher diagnostic efficiency in the follow-up of CIN Ⅱ-Ⅲ after CKC.关键词
宫颈上皮内瘤变/高级别/冷刀锥型切除术/二代杂交捕获技术/液基细胞学检测/随访/复发Key words
Cervical intraepithelial neoplasia/High grade/Cold knife conization/Hybrid captureⅡ technique/Thinprep cytologic test/Follow-up/Recrudescence分类
医药卫生引用本文复制引用
王佳丽,庞小芬,石丹丽,刘雪云,李春梅,莫凌昭..二代杂交捕获技术联合液基细胞学检测在宫颈高级别 上皮内瘤变患者冷刀锥型切除术后随访中的应用价值[J].广西医学,2018,40(10):1125-1128,4.基金项目
广西自然科学基金(2016GXNSFAA380026) （2016GXNSFAA380026）
