广西医学2018，Vol.40Issue(10)：1152-1154,3.DOI:10.11675/j.issn.0253-4304.2018.10.10
低分子肝素钙治疗重度、极重度慢性阻塞性肺疾病急性加重期患者的临床疗效
Clinical efficacy of low molecular weight heparin calcium for patients with severe and extremely severe acute exacerbation of chronic obstructive pulmonary disease
摘要
Abstract
Objective To investigate the clinical efficacy of low molecular weight heparin calcium for severe and extremely severe acute exacerbation of chronic obstructive pulmonary disease ( AECOPD ) . Methods A total of 128 patients with severe and extremely severe AECOPD were randomly divided into control group and treatment group,with 64 cases in each group;the control group was given conventional treatment such as oxygen therapy,anti-infection,bronchodilators,hormones,and non-invasive ventilation,while the treatment group was given low molecular weight heparin calcium additionally based on the therapies in the control group. The coagulation function and indices of blood gas analysis before and after treatment,as well as the effective rate of treatment were compared between the two groups. Results After one week of treatment,the total effective rate of the treatment group was higher than that of the control group(P<0. 05);the levels of fibrinogen degradation products( PDF) and D-dimer( DD) decreased in both groups than those before treatment,and the levels in the treatment group were lower than those in the control group;the level of PaO2 increased in both groups than that before treatment,and the level in the treatment group was higher than that in the control group;the level of PaCO2 decreased in both groups than that before treatment,and the level in the treatment group was lower than that in the control group(all P<0. 05). Conclusion Low molecular weight heparin calcium can effectively alleviate the symptoms of high coagulation,hypoxia and hypercapnia of patients with severe and extremely severe AECOPD,increase the effective rate of treatment,and improve patient prognosis,which is worthy of clinical application.关键词
低分子肝素钙/慢性阻塞性肺疾病/急性加重期Key words
Low molecular weight heparin calcium/Chronic obstructive pulmonary disease/Acute exacerbation分类
医药卫生引用本文复制引用
潘彩霞..低分子肝素钙治疗重度、极重度慢性阻塞性肺疾病急性加重期患者的临床疗效[J].广西医学,2018,40(10):1152-1154,3.基金项目
广西防城港市科学研究与技术开发计划(防科字[2014]15号) （防科字[2014]15号）
